765941-98-8Relevant academic research and scientific papers
Synthesis of α,α′-trans-oxepanes through an organocatalytic oxa-conjugate addition reaction
Lanier, Megan L.,Kasper, Amanda C.,Kim, Hyoungsu,Hong, Jiyong
supporting information, p. 2406 - 2409 (2014/05/20)
Oxepanes are found in a wide range of natural products; however, they are challenging synthetic targets due to enthalpic and entropic barriers. Organocatalytic oxa-conjugate addition reactions promoted by the gem-disubstituent (Thorpe-Ingold) effect stereoselectively provided α,α′-trans-oxepanes. In addition, the potential of an organocatalytic tandem oxa-conjugate addition/α-oxidation was demonstrated in a rapid generation of molecular complexity. These organocatalytic oxa-conjugate addition reactions would provide powerful tools for the synthesis of natural products that contain highly functionalized oxepanes.
Studies towards the synthesis of epothilone A via organoboranes
Ramachandran, P. Veeraraghavan,Chandra, J. Subash,Prabhudas, Bodhuri,Pratihar, Debarshi,Reddy, M. Venkat Ram
, p. 3812 - 3824 (2007/10/03)
Studies towards the synthesis of epothilone A via organoboranes have been described. A modified procedure for the large-scale preparation of B-γ,γ-dimethylallyldiisopinocampheylborane from prenyl alcohol has been developed. This reagent, upon reaction wit
Diastereoselective dihydroxylation and regioselective deoxygenation of dihydropyranones: A novel protocol for the stereoselective synthesis of C 1-C8 and C15-C21 subunits of (+)-discodermolide
Ramachandran, P. Veeraraghavan,Prabhudas, Bodhuri,Chandra, J. Subash,Reddy, M. Venkat Ram
, p. 6294 - 6304 (2007/10/03)
Diastereoselective dihydroxylation of dihydropyranones and subsequent regioselective α-deoxygenation provides 1,3-trans-β-hydroxy-6- lactones stereoselectively. This protocol has been applied for the synthesis of C1-C8 and C15-C21 subunits of (+)-discodermolide.
