765952-46-3

Upstream product

• 66-02-4 3,5-diiodotyrosine 
• 765952-44-1 methyl 2-tert-butoxycarbonyl-6,8-diiodo-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 765952-45-2 methyl 2-tert-butoxycarbonyl-6,8-diiodo-7-phenylethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 

Downstream Products

• 765952-48-5 ethyl 3-methoxycarbonyl-7-phenylethyl-1,2,3,4-tetrahydroisoquinoline-2-ethanoate 
• 765952-47-4 7-phenylethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 765952-42-9 methyl 7-phenylethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 

Relevant academic research and scientific papers

Synthesis of 7-phenylethoxy-1,2,3,4-tetrahydroiso- quinoline derivatives

Synthesis of 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives is described, from diiodotyrosine, using a Pictet-Spengler reaction and further O-alkylation of the aromatic ring providing compounds (1) and (2).