765955-46-2

Upstream product

• 765954-84-5 3-(4-amino-phenylsulfanyl)-4-(5-chloro-2-methoxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one 
• 765955-45-1 4-(5-chloro-2-hydroxy-phenyl)-3-(4-nitro-phenylsulfanyl)-6-trifluoromethyl-1H-quinolin-2-one 
• 761442-93-7 2-bromo-N-[2-(5-chloro-2-methoxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide 
• 761442-94-8 2-bromo-N-[2-(5-chloro-2-hydroxy-benzoyl)-4-trifluoromethyl-phenyl]-acetamide 
• 221113-32-2 (2-amino-5-trifluoromethyl-phenyl)-(5-chloro-2-methoxy-phenyl)-methanone 

Downstream Products

• 765954-85-6 2-bromo-N-{4-[4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-ylsulfanyl]-phenyl}-acetamide 
• 765954-86-7 N-{4-[4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-ylsulfanyl]-phenyl}-acrylamide 
• 765954-87-8 4-chloro-N-{4-[4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-3-ylsulfanyl]-phenyl}-butyramide 

Relevant academic research and scientific papers

Potassium channel modulators

This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.

Compounds for the treatment of male erectile dysfunction

This invention describes compounds of Formula (I) which are modulators of potassium channels and are useful for treating conditions affected by abnormal potassium channel activity including erectile dysfunction and irritable bowel syndrome.

3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction

A series Maxi-K openers for the treatment of erectile dysfunction based on the 3-thio-quinolinine core is described. Significant levels of channel opening (up to 550% of control) are seen in transfected oocytes. Functional activity in rabbit corpus cavemo