76603-26-4

Usage

Chemical structure

Pyrido-triazine derivative

Potential applications

Pharmaceutical

Studied for

Anticancer and antiviral properties

Activity

Promising against human cancer cell lines

Investigation

Potential use in the development of new anticancer drugs

Inhibitory activity

Against HIV-1 protease

Potential

Candidate for the development of new antiviral treatments

Significance

Unique chemical structure and therapeutic properties for further study and drug development

InChI:InChI=1/C14H12N4O/c1-10(19)18-13-7-8-15-9-12(13)16-14(17-18)11-5-3-2-4-6-11/h2-9H,1H3,(H,16,17)

Upstream product

• 60445-75-2 1,4-dihydro-3-phenylpyrido<3,4-e> as-triazine 

Relevant academic research and scientific papers

Pyrido?3,4-e!-as-triazines

Acylated pyrido ?3,4-e!-as-triazines of the formula (I), STR1 wherein R1 stands for alkyl, alkoxy, haloalkyl, furyl, pyridyl, phenyl, phenyl-(C1-4 alkyl) or phyenyl-(C2-4 alkenyl) optionally substituted. R2 stands for hydrogen or a group of the formula R1 --CO--, R3 stands for hydrogen, a phenyl group or a naphthy6l group optionally substituted, or a phenyl-(C1-4 alkyl) group, pyridyl group or a C1-20 alkyl group, and R4 stands for hydrogen or a group of the formula R1 --CO--, and R5 forms together with R2 or R4 a valence bond, wherein R2 or R4 taking part in forming said valence bond may not have the above meaning, and pharmaceutically acceptable acid addition salts thereof, which are prepared by reacting a pyrido ?3,4-e!-as-triazine of the formula (II) or an acid addition salt thereof STR2 R6 stands for hydrogen, and R5 forms together with R and R4 a valence bond, with an acylating agent of the formula (III). The compounds exert favourable effects on the central nervous system, and can be applied primarily as analgesic and antiphlogistic agents.