76605-41-9Relevant academic research and scientific papers
Method for preparing 5-substituted chiral hydantoin
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Paragraph 0035; 0036, (2017/02/28)
The invention discloses a method for directly preparing a 5-substituted chiral hydantoin compound by asymmetric catalyzing and hydrogenating of hydantoin-derived exocycloolefin. A chemical structural formula of the 5-substituted chiral hydantoin compound is expressed by a formula (I) shown in the description. A chemical reaction equation is shown in the description, wherein a compound (II) is the hydantoin-derived exocycloolefin; a compound (III) is a catalyst, and the catalyst is a metal compound of chiral diphosphine ligand. Compared with the prior art, the method has the characteristics that the chiral multiplication is realized, the efficiency and selectivity are high, the atom economy is realized, the green and non-pollution effects are realized, the industrialization is easy, and the like.
