76606-39-8

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE
• Synonyms: Albb-006691;[2-(4-fluorophenyl)-5-methyl-pyrazol-3-yl]amine;2-(4-fluorophenyl)-5-methyl-3-pyrazolamine;2-(4-fluorophenyl)-5-methyl-pyrazol-3-amine;2-(4-fluorophenyl)-5-methylpyrazol-3-amine
• CAS NO: 76606-39-8
• Molecular Formula: C₁₀H₁₀FN₃
• Molecular Weight: 191.21
• Mol File: 76606-39-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 326.9°C at 760 mmHg
• Flash Point: 151.5°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.00021mmHg at 25°C
• Refractive Index: 1.607
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE(76606-39-8)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-5-METHYL-2H-PYRAZOL-3-YLAMINE(76606-39-8)

Safety Data

• Hazardous Substances Data: 76606-39-8(Hazardous Substances Data)

Usage

Uses

1-(4-fluorophenyl)-3-methyl-1H-pyrazol-5-amine is used in the synthesis of novel spiro-?tethered pyrazolo[3,?4-?b]?quinoline hybrid through 1,3 dipolar cycloaddition.

InChI:InChI=1/C10H10FN3/c1-7-6-10(12)14(13-7)9-4-2-8(11)3-5-9/h2-6H,12H2,1H3

Upstream product

• 763-33-7 (E)-3-aminocrotononitrile 
• 371-14-2 4-fluorophenylhydrazine 
• 2469-99-0 Cyanoaceton 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 5417-82-3 (1-ethoxyethylidene)malononitrile 
• 1118-61-2 3-Aminocrotononitrile 

Downstream Products

• 1448705-04-1 C₁₇H₁₃F₃N₄O 
• 1398122-76-3 3-(4-fluorophenyl)-1-methyl-5-phenylnaphtho[1,8-fg]pyrazolo[3,4-c]isoquinolin-6(3H)-one 
• 1350908-58-5 4-[(bromo)(difluoro)methyl]-1-(4-fluorophenyl)-3 methyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one 
• 1350908-61-0 4-[(chloro)(difluoro)methyl]-1-(4-fluorophenyl)-3 methyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one 
• 1350908-51-8 C₂₀H₁₄F₃N₃OS 
• 1350908-64-3 4-[(chloro)(fluoro)methyl]-1-(4-fluorophenyl)-3 methyl-6,7-dihydro-1H-pyrazolo[3,4 b]pyridin-6-one 
• 105439-00-7 5-Benzylamino-1-(4-fluorophenyl)-3-methyl-4-nitrosopyrazole 
• 105438-58-2 1-(4-Fluoro-phenyl)-3-methyl-5-phenyl-1,6-dihydro-imidazo[4,5-c]pyrazole 
• 105438-85-5 5-Benzylamino-1-(4-fluorophenyl)-3-methylpyrazole 
• 105438-99-1 5-Ethylamino-1-(4-fluorophenyl)-3-methyl-4-nitrosopyrazole 
• 105438-57-1 1-(4-Fluoro-phenyl)-3,5-dimethyl-1,6-dihydro-imidazo[4,5-c]pyrazole 
• 105438-84-4 5-Ethylamino-1-(4-fluorophenyl)-3-methylpyrazole 

Relevant articles and documents

Oxidative Ring-Opening of 1H-Pyrazol-5-amines and Its Application in Constructing Pyrazolo–Pyrrolo–Pyrazine Scaffolds by Domino Cyclization

Herein, an oxidative ring-opening of 1H-pyrazol-5-amines to form 3-diazenylacrylonitrile derivatives under mild and transition-metal-free conditions is described. In addition, the nucleophilic addition of deprotonated 1H-pyrrole-2-carbaldehydes to the vinyl moiety of the yielded 3-diazenylacrylonitriles could trigger domino cyclization to afford the 3H-pyrazolo[3,4-e]pyrrolo[1,2-a]pyrazine derivatives. Computational studies suggest that the oxidation of 1H-pyrazol-5-amines in the presence of PhIO is through the formation of a hydroxylamine intermediate followed by elimination of H2O to result in the ring-opening product. The detailed domino cyclization pathway leading to the pyrazolo–pyrrolo–pyrazine scaffolds is revealed.

Efficient catalyst-free tricomponent synthesis of new spiro[cyclohexane-1,4′-pyrazolo[3,4-e][1, 4]thiazepin]-7′(6′H)-ones

A series of spirocyclohexane-1,4′-pyrazolothiazepinones were synthesized by one-pot multicomponent cyclocondensation reactions between 5-amino-1-arylpyrazoles, cyclohexanone and mercaptoacetic acid with good yields and easy purification protocols. Some control experiments involving isolation of reaction intermediates were performed leading to the proposal of three alternative mechanistic pathways conducting to the named spiroheterocycles. All target molecules were fully characterized by IR, NMR, melting point and HRMS.

Application of 5-aminopyrazole compounds to plant growth regulation aspect

The invention discloses application of 5-aminopyrazole compounds to plant growth regulation aspect in the technical field of pesticide compounds, in particular to application of the 5-aminopyrazole compounds shown by the formula to the plant growth regulation aspect, particularly the application to the plant growth inhibition. The formula I is shown in the description. The compound shown in the formula I can be used as a weedicide; weeds in places such as highway and railway can be killed through regulating the concentration of the 5-aminopyrazole compounds, wherein the R1 is hydrogen or alkylor phenyl or substituted phenyl; R2 is alkyl; R3 is hydrogen or halogen.