76617-97-5

Upstream product

• 853029-98-8 4-oxo-3,4-dihydroquinazoline-2-carbonitrile 
• 29113-33-5 ethyl 4-oxo-3,4-dihydro-2-quinazolinecarboxylate 
• 31143-83-6 ethyl 4-oxo-1,4-dihydro-2H-3,1-benzoxazine-2-carboxylate 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 898044-49-0 4-chloroquinazoline-2-carbonitrile 
• 1415355-74-6 C₁₆H₁₀N₄O₄ 
• 1448025-14-6 3-[3-(2-methylphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1448025-15-7 3-[3-(2-methoxyphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1448025-16-8 ethyl 2-[3-(2-carbamoyl-4-oxoquinazolin-3(4H)-yl)prop-1-yn-1-yl]benzoate 
• 1448025-17-9 3-[3-(4-methylphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1448025-18-0 3-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carboxamide 
• 1448025-19-1 ethyl 4-[3-(2-carbamoyl-4-oxoquinazolin-3(4H)-yl)prop-1-yn-1-yl]benzoate 
• 1448025-20-4 3-[3-(2-methylphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carbonitrile 
• 1448025-21-5 3-[3-(2-methoxyphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carbonitrile 
• 1448025-22-6 ethyl 2-[3-(2-cyano-4-oxoquinazolin-3(4H)-yl)prop-1-yn-1-yl]benzoate 
• 1448025-23-7 3-[3-(4-methylphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carbonitrile 
• 1448025-24-8 3-[3-(4-methoxyphenyl)prop-2-yn-1-yl]-4-oxo-3,4-dihydroquinazoline-2-carbonitrile 
• 1448025-25-9 ethyl 4-[3-(2-cyano-4-oxoquinazolin-3(4H)-yl)prop-1-yn-1-yl]benzoate 

Relevant academic research and scientific papers

Synthesis and Chemistry of Benzo[ e][1,2,6]thiadiazino[3,4- b][1,4]diazepin-10(11 H)-ones and Related Ring Transformations

2-[(3,5-Dichloro-4H-1,2,6-thiadiazin-4-ylidene)amino]benzamides are cyclized to benzo[e][1,2,6]thiadiazino[3,4-b][1,4]diazepin-10(11H)-ones via (i) treatment with NaH and via (ii) Pd-catalyzed C-N coupling. The behavior of the latter toward nucleophiles a

Disubstituted bicyclic derivative and application thereof as efflux pump inhibitor to anti-microbial

The invention discloses a disubstituted bicyclic derivative and application thereof as an efflux pump inhibitor to anti-microbial. It is proved by experiments that the disubstituted bicyclic derivative has a good inhibition function on multidrug-resistant bacteria carrying an AcrB efflux pump and can effectively recover or enhance antibacterial efficiency of existing antibiotics. The chemical structural formula of the disubstituted bicyclic derivative is as shown in a formula (I) (the formula can be seen in specification), and R1, R2, X, Y, Z and W are as defined in the specification.

An efficient and selective access to 1-substituted and 3-substituted derivatives of luotonin A Dedicated with best wishes to Professor Gottfried Heinisch on the occasion of his 75th birthday

A method for the selective introduction of a substituent into position 1 or position 3 of the antitumour alkaloid, luotonin A, is described. The protocol involves a base-catalysed intramolecular [4+2] cycloaddition reaction of an arylpropargyl unit with a

Synthesis and configurational assignment of 1,2-dihydroimidazo[5,1-b] quinazoline-3,9-diones: Novel NMDA receptor antagonists

NMDA receptors form a major subdivision of the ionotropic glutamate receptor family that mediates excitatory synaptic transmission in the brain. Series of 1-substituted 1,2-dihydroimidazo[5,1-b]quinazolinediones were synthesized and found to have potent nanomolar activity at the glycine site of the NMDA receptor. Imidazoquinazolinediones were prepared by cyclocondensation of 4-oxo-quinazoline-2-carboxamide with aldehydes and orthoesters with good yields. The formed enantiomers were separated by chiral HPLC. The absolute configuration of pure enantiomers is elucidated by combined CD/Quantumchemical time-dependent DFT calculation method (TDDFT).

Synthesis of Some New 4-Quinazolinone-2-carboxy Esters, 2-Carboxamides, 2-Carboxyhydrazides and Their Tosyl Derivatives Having Potential Biological Activity

Some new 2-carbethoxy-3,4-dihydro-4-oxoquinazolines (II) and their derivatives such as 2-carboxamides (III), carboxyhydrazides (IV) and the tosylhydrazides (V) have been synthesized.The antitubercular activity of IV has been determined.