7663-26-5Relevant academic research and scientific papers
Chirality-Driven Mode of Binding of α-Aminophosphonic Acid-Based Allosteric Inhibitors of the Human Farnesyl Pyrophosphate Synthase (hFPPS)
Feng, Yuting,Park, Jaeok,Li, Shi-Guang,Boutin, Rebecca,Viereck, Peter,Schilling, Matthew A.,Berghuis, Albert M.,Tsantrizos, Youla S.
, p. 9691 - 9702 (2019/11/03)
Thienopyrimidine-based allosteric inhibitors of the human farnesyl pyrophosphate synthase (hFPPS), characterized by a chiral α-aminophosphonic acid moiety, were synthesized as enantiomerically enriched pairs, and their binding mode was investigated by X-ray crystallography. A general consensus in the binding orientation of all (R)- and (S)-enantiomers was revealed. This finding is a prerequisite for establishing a reliable structure-activity relationship (SAR) model.
UNUSUAL AMINO ACIDS II. Asymmetric Synthesis of Fluorine Containing Phenylalanines
Krause, Hans-Walter,Kreuzfeld, Hans-Joern,Doebler, Christian,Taudien, Stefan
, p. 555 - 566 (2007/10/02)
Few (Z)-α-N-benzoylamino-β-(fluorophenyl)-acrylic acids and their esters were prepared by known procedures and hydrogenated to the corresponding optically active α-benzoyl-β-(fluorophenyl)-alanine derivatives with optical yields up to 90percent using the
