76639-75-3Relevant academic research and scientific papers
Some Reactions of 1,4-Dihydropyridines with Organic Azides. Synthesis of 2,7-Diazabicyclohept-3-enes with Analgesic and Antiprotozoal Activity
Warren, Brent K.,Knaus, Edward E.
, p. 462 - 464 (2007/10/02)
The 1,3-dipolar cycloaddition reaction of 1,4-dihydropyridines, 2, with organic azides, 3, afford 2,7-diazabicyclohept-3-enes, 4, which exhibit significant analgesic and antiprotozoal activities.The most active analgesics, 4a and 4c, were more potent than aspirin or dextropropoxyphene.Diazabicyclohept-3-enes 4a-e exert potent antiprotozoal activity, inhibiting growth of Trichomonas vaginalis at concentrations of less than 10 μg/mL of medium.The broad spectrum pharmacological screen also revealed moderate hypoglycemic (4a), antiinflammatory (4c), antidepressant (4d and 4e) and antihistaminic (4f) activities.
