766451-13-2

Upstream product

• 56327-03-8 8-(4-fluoro-phenyl)-1,4-dioxa-spiro[4.5]decane-8-carboxylic acid 
• 56327-11-8 Acetic acid 1-(4-fluoro-phenyl)-4-hydroxy-cyclohexylmethyl ester 
• 56327-07-2 Acetic acid 1-(4-fluoro-phenyl)-4-oxo-cyclohexylmethyl ester 
• 56327-16-3 4-cis-acetoxymethyl-4-trans-(4-fluorophenyl)cyclohexanol, methanesulfonate 

Relevant academic research and scientific papers

Butyrophenones as hypotensive agents. Derivatives of 4 aryl 4 (hydroxymethyl)cyclohexylamine

The preparation of butyrophenone derivatives of 4 aryl 4 (hydroxymethyl) cyclohex 1 ylamines starting from the corresponding 4 cyano 4 phenylcyclohexan 1 ones is described. Substitution was varied in both rings; both isomers of 4 phenyl 4 (hydroxymethyl)cyclohex 1 ylamine were characterized. Those derivatives which carried p fluoro substitution on the butyrophenone exhibited hypotensive activity in the rat with diminished CNS activity compared to compounds lacking the hydroxymethyl group. The effect of substitution on the 4 aryl ring is discussed.