766496-29-1Relevant academic research and scientific papers
Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer
Penning, Thomas D.,Zhu, Gui-Dong,Gandhi, Viraj B.,Gong, Jianchun,Thomas, Sheela,Lubisch, Wilfried,Grandel, Roland,Wernet, Wolfgang,Park, Chang H.,Fry, Elizabeth H.,Liu, Xuesong,Shi, Yan,Klinghofer, Vered,Johnson, Eric F.,Donawho, Cherrie K.,Frost, David J.,Bontcheva-Diaz, Velitchka,Bouska, Jennifer J.,Olson, Amanda M.,Marsh, Kennan C.,Luo, Yan,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 6965 - 6975 (2008)
We have developed a series of cyclic amine-containing benzimidazole carboxamide poly(ADP-ribose)polymerase (PARP) inhibitors, with good PARP-1 enzyme potency, as well as cellular potency. These efforts led to the identification of a lead preclinical candi
