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Usage

Uses

Used in Pharmaceutical Industry:
(1S)-1-(4-CHLOROPHENYL)-2,2,2-TRIFLUOROETHYLAMINE is used as an intermediate or starting material for the production of various pharmaceuticals, contributing to the development of new medications due to its unique chemical properties and reactivity.
Used in Agrochemical Industry:
In the agrochemical sector, (1S)-1-(4-CHLOROPHENYL)-2,2,2-TRIFLUOROETHYLAMINE is utilized as a precursor in the synthesis of agrochemicals, playing a crucial role in the creation of effective and targeted pest control solutions.
Used in Organic Synthesis:
(1S)-1-(4-CHLOROPHENYL)-2,2,2-TRIFLUOROETHYLAMINE is employed as a reagent in organic synthesis, particularly for the formation of carbon-carbon and carbon-heteroatom bonds, which are fundamental in constructing complex organic molecules.
Used in Drug Discovery:
(1S)-1-(4-CHLOROPHENYL)-2,2,2-TRIFLUOROETHYLAMINE is used as a building block in creating diverse chemical libraries for drug discovery, providing a foundation for the exploration of new therapeutic agents and chemical entities with potential medicinal applications.

InChI:InChI=1/C8H7ClF3N/c9-6-3-1-5(2-4-6)7(13)8(10,11)12/h1-4,7H,13H2/t7-/m0/s1

Upstream product

• 1453102-14-1 (R)-N-[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]-4-meth-oxyaniline 
• 321-37-9 4'-chloro-2,2,2-trifluoroacetophenone 

Relevant academic research and scientific papers

Silver-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides: a facile stereoselective synthesis of CF3-substituted heterocycles

An Ag-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides with polar double bonds has been developed for the facile access to trifluoromethylated oxazolines, imidazolines and pyrrolines under mild conditions. The practicality of this chemistry is demonstrated by the gram-scale synthesis of oxazolines with excellent yields and facile transformations of the formed oxazolines to trifluoromethylated β-amino alcohols in quantitative yields.

Enantioselective synthesis of α-trifluoromethyl arylmethylamines by ruthenium-catalyzed transfer hydrogenation reaction

A simple combination of dichloro(para-cymene)ruthenium(II) dimer, a chiral amino alcohol and isopropyl alcohol allowed for in-situ generation of the bifunctional catalyst responsible for the transfer hydrogenation reaction of trifluoromethyl ketimines in excellent yields with high enantioselectivities (up to 93% ee). Herein, we describe the optimization, scope, limitations, and applications of the method.

Aryltrifluoroethylamines

Certain arylmethyl amines have been prepared wherein the "methyl" carbon is substituted with a polyfluoroalkyl radical. The compounds form acid addition salts, exist in resolvable stereoisomeric forms, and are useful for treating hypertension. Formulations for human and veterinary medicine are described, as well as methods of use.