766519-89-5

Basic information

• Product Name: 5-(3-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE
• Synonyms: 5-(3-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE;CHEMBRDG-BB 4010171;3-Amino-5-(3-fluorophenyl)-1H-pyrazole;OTAVA-BB 1196718;5-(3-fluorophenyl)-1H-Pyrazol-3-amine
• CAS NO: 766519-89-5
• Molecular Formula: C₉H₈FN₃
• Molecular Weight: 177.18
• Mol File: 766519-89-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 441.2°C at 760 mmHg
• Flash Point: 220.7°C
• Appearance: /
• Density: 1.334g/cm³
• Vapor Pressure: 5.53E-08mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• PKA: 14.08±0.10(Predicted)
• CAS DataBase Reference: 5-(3-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE(766519-89-5)
• EPA Substance Registry System: 5-(3-FLUORO-PHENYL)-2H-PYRAZOL-3-YLAMINE(766519-89-5)

Safety Data

• Hazardous Substances Data: 766519-89-5(Hazardous Substances Data)

Usage

General Description

5-(3-fluoro-phenyl)-2H-pyrazol-3-ylamine is a chemical compound with the molecular formula C9H8FN3. It is a derivative of pyrazole and contains a fluorophenyl group and an amine group. 5-(3-fluoro-phenyl)-2H-pyrazol-3-ylamine is a potential building block for the synthesis of various bioactive molecules due to its unique structure and reactivity. It may have potential applications in the development of pharmaceuticals, agrochemicals, and materials science. Additionally, it could be used in research and development in the fields of medicinal chemistry and chemical biology. Overall, 5-(3-fluoro-phenyl)-2H-pyrazol-3-ylamine has the potential to serve as a valuable tool for the synthesis of diverse chemical compounds with a range of potential applications.

InChI:InChI=1/C9H8FN3/c10-7-3-1-2-6(4-7)8-5-9(11)13-12-8/h1-5H,(H3,11,12,13)

Upstream product

• 455-38-9 3-fluorobenzoic acid 
• 456-48-4 3-Fluorobenzaldehyde 
• 455-68-5 methyl 3-fluorobenzoate 
• 21667-61-8 3-fluorobenzoylacetonitrile 

Downstream Products

• 948881-91-2 C₁₈H₂₃FN₄O 
• 1606126-49-1 N-[3-(3-fluorophenyl)-1H-pyrazol-5-yl]acetamide 
• 1606126-50-4 N-[3-(3-fluorophenyl)-4-iodo-1H-pyrazol-5-yl]acetamide 
• 1606126-51-5 N-[3-(3-fluorophenyl)-4-(2-phenylethynyl)-1H-pyrazol-5-yl]acetamide 
• 1606126-52-6 3-(3-fluorophenyl)-4-(2-phenylethynyl)-1H-pyrazol-5-amine 
• 1606126-53-7 4-chloro-3-(3-fluorophenyl)-5-phenyl-1H-pyrazolo[3,4-c]pyridazine 
• 1606126-31-1 4-[2-[4-chloro-3-(3-fluorophenyl)-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl]ethyl]morpholine 
• 1606126-30-0 4-chloro-3-(3-fluorophenyl)-1-[2-(4-methylpiperazin-1-yl)ethyl]-5-phenyl-pyrazolo[3,4-c]pyridazine 
• 1363184-52-4 3-(3-fluoro-phenyl)-4-hydroxy-4-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-b]pyridin-6-one 
• 1269515-38-9 2-(3-fluorophenyl)-6-nitropyrazolo[1,5-a]pyrimidine 
• 1269515-39-0 2-(3-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-amine 
• 1269515-37-8 2,6-difluoro-N-(2-(3-fluorophenyl)pyrazolo[1,5-a]pyrimidin-6-yl)-3-(propylsulfonamido)benzamide 

Relevant articles and documents

Synthesis of Pyrazole Compounds by Using Sonication Method

A simple method for the synthesis of pyrazoles derivatives carried out by cyclization of cyanide with hydrazine hydrate by using sonication method. All the prepared compounds were characterized by 1H, 13C NMR and IR Spectroscopy.

Modular synthesis and antiproliferative activity of new dihydro-1H-pyrazolo[1,3-b]pyridine embelin derivatives

A set of new dihydro-1H-pyrazolo[1,3-b]pyridine and pyrazolo[1,3-b]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure–activity relationships were out-lined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative values.

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS

The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can a