766556-63-2Relevant academic research and scientific papers
Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties
Corte, James R.,Fang, Tianan,Pinto, Donald J.P.,Han, Wei,Hu, Zilun,Jiang, Xiang-Jun,Li, Yun-Long,Gauuan, Jolicia F.,Hadden, Mark,Orton, Darren,Rendina, Alan R.,Luettgen, Joseph M.,Wong, Pancras C.,He, Kan,Morin, Paul E.,Chang, Chong-Hwan,Cheney, Daniel L.,Knabb, Robert M.,Wexler, Ruth R.,Lam, Patrick Y.S.
, p. 2845 - 2849 (2008/12/21)
Introduction of the phenyl piperidinone and phenyl pyridinone P4 moieties in the anthranilamide scaffold led to potent, selective, and orally bioavailable inhibitors of factor Xa. Anthranilamide 28 displayed comparable efficacy to apixaban in the rabbit a
LACTAM-CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS
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Page/Page column 117, (2010/02/08)
The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trysin-like serine proteases, specifically factor Xa.
