76659-81-9Relevant academic research and scientific papers
SYNTHESIS AND SODIUM BOROHYDRIDE REDUCTION OF 3,9-DIMETHYLADENINE PERCHLORATE DEUTERATED AT THE 2-POSITION
Fujii, Tozo,Saito, Tohru,Nakasaka, Tsuyoshi,Kizu, Kyoko
, p. 1729 - 1734 (2007/10/02)
The NaBH4 reduction reduction of 3,9-dimethyladenine perchlorate (Ib) in MeOH was found to give the 1,2-dihydro derivative III.The structure of III was confirmed by a similar reduction of the 2-deuterated isomer XIV, which was synthesized from the methylaminoimidazole VI through the deuteroformamido derivatives VIII and XI. 3-Benzyl-9-methyladenine-2-d perchlorate (XV) was similarly prepared from the N-benzylformamidoimidazole V through the deformylated derivative VII and the deuteroformamido derivatives IX and XII.Comparison of the nmr spectra of Ib and 3-benzyl-9-methyladenine perchlorate (Ie) with those of XIV and XV permitted a distinction between C(2)- and C(8)-proton signals observed for 3,9-dialkyladenine salts (Ia-1); the C(2)-proton resonates at lower field than does the C(8)-proton.
