76662-96-9

Basic information

• Product Name: 2-(2,3-dihydro-1H-inden-5-ylamino)-N-(4-sulfamoylphenyl)acetamide
• Synonyms: 2-(2,3-dihydro-1H-inden-5-ylamino)-N-(4-sulfamoylphenyl)acetamide
• CAS NO: 76662-96-9
• Molecular Weight: 345.422
• Mol File: 76662-96-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2,3-dihydro-1H-inden-5-ylamino)-N-(4-sulfamoylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,3-dihydro-1H-inden-5-ylamino)-N-(4-sulfamoylphenyl)acetamide(76662-96-9)
• EPA Substance Registry System: 2-(2,3-dihydro-1H-inden-5-ylamino)-N-(4-sulfamoylphenyl)acetamide(76662-96-9)

Safety Data

• Hazardous Substances Data: 76662-96-9(Hazardous Substances Data)

Upstream product

• 24425-40-9 indan-5-amine 
• 14949-01-0 2-chloro-N-(4-sulfamoylphenyl)acetamide 

Relevant articles and documents

Cytotoxic activity of some novel sulfonamide derivatives

The versatile synthons 2-chloro-N-(4-sulfamoylphenyl)acetamides 1a,b were used as a key intermediates for the synthesis of sulfonamide derivatives with adamantyl 2, indene 3, morpholinophenyl 4, pipronyl 5, benzothiazole 6-8, pyrazole 9, thiadiazole 10, 11, quinoline 12, isoquinoline 13, thiazoles 14-19, acrylamides 20-24 and benzochromene 25 moieties via reaction with several nitrogen nucleophiles. The newly synthesized compounds were screened in vitro for their anticancer activity against breast cancer (MDA-MB-231) and colon cancer (HT-29) cell lines. Compound 17 was found to be the most potent against breast cancer cell lines with IC50 value 66.6 μM compared with the reference drug 5-fluorouracil with IC50 value 77.28 μM. Keywords: synthesis, sulfonamides, anticancer activity The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding of this research through the Research Group Project no. GP-VPP-302.