76672-27-0

Usage

Compound type

Chemical compound, derivative of quinoxalinone

Structure

Bicyclic heteroaromatic organic compound with a chloro and a methyl group on the quinoxalinone ring

Usage

Building block in the synthesis of more complex organic molecules

Biological activity

Known to exhibit biological activity, of interest to pharmaceutical and medicinal chemistry research

Value

Valuable in various chemical and industrial applications due to its unique structural features and reactivity.

Upstream product

• 127-17-3 2-oxo-propionic acid 
• 95-83-0 4-Chloro-1,2-phenylenediamine 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 34797-69-8 p-chloro-o-nitroacetoacetanilide 

Downstream Products

• 76672-21-4 3,6-dichloro-2-methylquinoxaline 
• 76672-20-3 2,6-dichloro-2-methylquinoxaline 

Relevant academic research and scientific papers

Aqueous hydrofluoric acid catalyzed facile synthesis of 2,3,6-substituted quinoxalines

A versatile synthetic route for the preparation of 2,3,6-trisubstituted quinoxalines in excellent yield is developed from θ-diamines and 1,2-dicarbonyl compounds in which aqueous hydrofluoric acid was employed as the medium and catalyst. Other salient features of this protocol include milder conditions, absence of coupling agents, and easy workup procedures.

TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS

The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders.

TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS

The present invention provides compounds of formula (Ia) and (Ib) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

NON-PEPTIDE GLP-1 AGONISTS

Novel non-peptide GLP-1 agonists, pharmaceutical compositions comprising them, use of the non-peptide GLP-1 agonists for the preparation of pharmaceutical compositions and methods for the treatment and/or prevention of disorders and diseases wherein an ac

The facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones

Facile one pot synthesis of 6-substituted 2(1H)-quinoxalinones and these reaction mechanisms are described.The intramolecular cyclization reaction of 4'-substituted 2'-nitroacetoacetanilides in aqueous basic medium and the reduction of 6-substituted 2(1H)-quinoxalinone-4-oxide wit sodium borohydride or sodium hydrogensulfite were studied in detail