76698-69-6

Upstream product

• 104-82-5 4-Methylbenzyl chloride 
• 670-54-2 ethenetetracarbonitrile 
• 79439-44-4 C₁₆H₁₈OSe 
• 3425-46-5 potassium selenocyanate 
• 104-81-4 4-Methylbenzyl bromide 

Downstream Products

• 76698-72-1 bis(4-methylbenzyl) selenide 
• 65915-30-2 bis-4-(methylbenzyl)-diselenide 
• 538-39-6 1,2-di-p-tolylethane 
• 104-82-5 4-Methylbenzyl chloride 

Relevant academic research and scientific papers

(1-Selenocyanatoethyl)benzene: A Selenocyanation Reagent for Site-Selective Selenocyanation of Inert Alkyl C(sp3)-H Bonds

A new, simple, yet easily accessible, (1-selenocyanatoethyl)benzene has been designed and applied as a SeCN group transfer reagent for selenocyanation of aliphatic C(sp3)-H bonds for the first time. This protocol is featured with mild reaction conditions and wide substrate scope. Control experiments reveal that a radical-group transfer mechanism might be involved.

Pronounced activity of aromatic selenocyanates against multidrug resistant ESKAPE bacteria

Selenocyanates represent an interesting class of organic selenium compounds. Due to their similarity with better known natural (iso-)thiocyanates, they promise high biological activity and may also be metabolized to other Reactive Selenium Species (RSeS),

Selenocyanates and diselenides: A new class of potent antileishmanial agents

Thirty five selenocyanate and diselenide compounds were subjected to in vitro screening against Leishmania infantum promastigotes and the most active ones were also tested in an axenic amastigote model. In order to establish the selectivity indexes (SI) t

Reactions of Benzylic Compounds. Nucleophilicity, Leaving Group Ability and Carbon Basicity of some Ionic Nucleophiles in Acetonitrile. Comments on the Utility of the Finkelstein Reaction in Synthesis

The reactions of some 4-substituted benzylic compounds, 4-Z-PhCH2X, with various ionic nucleophiles, Y(-), (Z = NO2, H and Me; X and Y = Cl,Br,SCN and SeCN) have been studied under homogeneous conditions in acetonitrile at 25.0 deg C.All the reactions have been found to proceed through nucleophilic attack at the methylene carbon atom.Isothiocyanates, 4-Z-PhCH2NCS, and isoselenocyanates, 4-Z-PhCH2NCSe, are not formed.The reactions obey second-order kinetics, first order in each of the reactants.The halide ions and the selenocyanate ion show similar nucleophilic strength and are five to ten times as reactive as the thiocyanate ion.The average leaving group ability is I(-) > Br(-) >> Cl(-) > NCSe(-) > NCS(-).From the equilibrium constants the average carbon basicity order is NCSe(-) ca.NCS(-) ca.Cl(-) >> Br(-) > I(-).The relative basicity of NCSe(-), NCS(-) and Cl(-) is slightly dependent upon Z; in 4-Me-PhCH2X the order is NCS(-) >/= NCSe(-) > Cl while in 4-NO2-PhCH2X the order is NCSe(-) > NCS(-) ca.Cl(-).The tellurocyanate ion, NCTe(-), is ten times as reactive as NCSe(-) toward 4-NO2-PhCH2Cl and no equilibrium is established (K > 1E4).The reaction product is an addition compound from the first formed organic tellurocyanate and the displaced chloride ion, the (-) - anion, a Te(II)-tellurate.The results from an X-ray structure determination of is presented in brief.In the adduct Cl is trans to the cyano group and the Te-Cl bond, 2.923(2) Angstroem, is more than 1 Angstroem shorter than the sum of the van der Waal's radii.