76705-48-1

Upstream product

• 138194-47-5 O-methyltetronolide 
• 910043-25-3 (+)-tert-butyl 2α-bromomethyl-8aβ-isopropoxycarbonyl-(5,6)-β-epoxy-4aβ,5,6,7,8,8a-hexahydro-4H-1,3-benzodioxin-7α-carboxylate 
• 910043-02-6 (+)-tert-butyl 2α-bromomethyl-8aβ-isopropoxycarbonyl-5β-hydroxy-4aβ,5,8,8a-tetrahydro-4H-1,3-benzodioxin-7-carboxylate 
• 910042-98-7 tert-butyl (2E,4E)-octa-2,4,6-trienoate 
• 910043-00-4 tert-butyl (E,E)-6-formylpenta-2,4-dienoate 
• 138213-60-2 C₅₁H₇₆O₁₄SSi 
• 138194-44-2 C₅₁H₈₆O₁₃Si₂ 
• 138194-45-3 C₄₅H₆₀O₁₃S 
• 138213-57-7 C₄₅H₆₀O₁₃S 
• 138194-48-6 C₅₁H₈₈O₁₃Si₂ 
• 138194-46-4 C₃₉H₅₄O₁₁ 
• 138213-58-8 (5S,9S,10R)-7-Dimethoxymethyl-4-methoxy-9-methoxymethoxy-10-[(E)-2-methyl-3-(2-trimethylsilanyl-ethoxymethoxy)-propenyl]-1-oxa-spiro[4.5]deca-3,7-dien-2-one 
• 138194-43-1 (1S,2S,4aS,5S,6S,8S,8aR)-2-[(E)-3-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-propenyl]-5-methoxymethoxy-1,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbaldehyde 
• 136786-24-8 tert-butyl (E,E)-6-hydroxyhexa-2,4-dienoate 

Relevant academic research and scientific papers

Toward the development of a general chiral auxiliary. A total synthesis of (+)-tetronolide via a tandem ketene-trapping [4 + 2] cycloaddition strategy

A highly convergent, enantioselective total synthesis of the aglycone of the tetrocarcins, (+)-tetronolide, is described. The synthesis highlights the use of several new methods, including camphor auxiliary-directed asymmetric alkylation and the enantiose

Total synthesis of tetronolide, the aglycon of tetrocarcins

The first total synthesis of tetronolide (1) has been achieved via coupling of spirotetronate 3 with octahydronaphthalene aldehyde 17 and subsequent macrocyclization of ω-sulfone-α-aldehyde 2, leading to confirmation of the absolute configuration of 1.