76706-66-6Relevant academic research and scientific papers
(+)-Cystothiazole G: Isolation and structural elucidation
Akita, Hiroyuki,Sasaki, Takamitsu,Kato, Keisuke,Suzuki, Yoshihiro,Kondo, Keiko,Sakagami, Youji,Ojika, Makoto,Fudou, Ryosuke,Yamanaka, Shigeru
, p. 4735 - 4738 (2004)
Palladium-catalyzed cyclization-methoxycarbonylation of (2R,3S)-3-methylpent-4-yne-1,2-diol (6) derived from (2R,3S)-epoxybutanoate 5 followed by methylation gave the tetrahydro-2-furylidene acetate (-)-7, which was converted to the left-half aldehyde (+)-3. A Wittig reaction between (+)-3 and the phosphoranylide derived from the bithiazole-type phosphonium iodide 4 using lithium bis(trimethylsilyl)amide afforded the (+)-cystothiazole G (2), whose spectral data were identical with those of the natural product (+)-2. Thus, the stereochemistry of cystothiazole G (2) was proved to be (4R,5S,6(E)).
