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Usage

Uses

Used in Pharmaceutical and Fine Chemical Synthesis:
alpha,alpha'-dimethylpiperazine-1,4-diethanol is used as a building block for the synthesis of pharmaceuticals and fine chemicals due to its versatile chemical properties.
Used in Metal Extraction and Separation Processes:
alpha,alpha'-dimethylpiperazine-1,4-diethanol is used as a chelating agent for forming coordination complexes with metal ions, which aids in metal extraction and separation processes.
Used in Industrial Applications:
alpha,alpha'-dimethylpiperazine-1,4-diethanol is used as a potential corrosion inhibitor to protect materials from degradation in various industrial applications.

Upstream product

• 110-85-0 piperazine 
• 75-56-9 methyloxirane 
• 13173-24-5 N,N'-bis-allylpiperazine 
• 2917-98-8 N,N'-bis(2,3-epoxypropyl)piperazine 

Relevant academic research and scientific papers

Binuclear and mononuclear Cu(II) and Ni(II) complexes of tetra- and hexadentate ligands: Synthesis, antifungal activity, spectroscopic and thermal characterization

Two tetradentate ligands, 1,2-bis(2-hydroxyethylthio)ethane S2O2 (L1) and N,N′-bis(2-hydoxypropyl)piperazine N2O2 (L2), were prepared by organization of some mononuclear complexes of Cu(II) and Ni(II). A new binuclear Schiff base ligand with a 1,4-dipropoxybutane spacer provided by the reaction of salicylaldehyde and 1,4-bis(3-aminopropoxy)butane served as an octadentate, N2O4 (L3) ligand, in designing some binuclear complexes with metal ions. All the ligands were characterized by elemental analyses, FTIR, 1H and 13C NMR and GC–MS. The complexes were characterized by elemental analyses, FTIR, thermal methods, electronic spectra, conductivity and magnetic measurements. The metal ions coordinate to the ligands with four donor atoms in square planar geometry. The thermal stabilities of the complexes were discussed in terms of metal ions and type of donor atoms. The complexes were characterized by electronic spectra and magnetic susceptibility measurements to establish the proposed four-coordinated square planar geometry. The TG chart indicates high thermal stability for complexes. The decomposition processes consisted of three stages: The first two stages involve the loss of water and chloride anions and the last stage indicates degradation of the organic ligands. The antifungal activity of the ligands and their complexes was tested against several fungal species: Aspergillus nigar, Aspergillus flavus and Candida albicans. The results show that complexes have significant antifungal activities compared to their parent ligands.

PLATINUM COMPOUNDS THAT INHIBIT CONSTITUTIVE STAT3 SIGNALING AND INDUCE CELL CYCLE ARREST AND APOPTOSIS OF MALIGNANT CELLS

The subject invention concerns a compound and compositions having activity as an inhibitor of Stat3 protein and methods of using the compound and compositions. In one embodiment, a compound of the invention has the structure shown in formula I, formula II, or formula III. The subject invention also concerns methods of using the compounds and compositions of the invention.

SYNTHESES OF PIPERAZINES SUBSTITUTED ON THE NITROGEN ATOMS WITH ALLYL, PROPYL, 2-HYDROXYPROPYL AND 3-HYDROXYPROPYL GROUPS

The paper describes synthesis of 1,4-diallylpiperazine (I), 1-allylpiperazine (III), 1-propylpiperazine (IV), 1-(1-piperazinyl)-2-propanol (V), 3-(1-piperazinyl)-1-propanol (VI), 1-allyl-4-propylpiperazine (VII), 1-(4-allyl-1-piperazinyl)-2-propanol (VIII), 3-(4-allyl-1-piperazinyl)-1-propanol (IX), 1,4-dipropylpiperazine (X), 1-(4-propyl-1-piperazinyl)-2-propanol (XI), 3-(4-propyl-1-piperazinyl)-1-propanol (XII), 1,4-bis(2-hydroxypropyl)piperazine (XIII), 3--1-propanol (XIV) and 1,4-bis(3-hydroxypropyl)piperazine (XV).Retention indices of I-XV are reported and mass spectra of the compounds are discussed.

HYDROBORATION OF 1,4-DIALLYLPIPERAZINE

Hydroboration of 1,4-diallylpiperazine (I) with triethylamine-borane afforded 5,8-diaza-1,9-diboradispirotetradecane (II). 1,4-Diallylpiperazine dihydrochloride reacted with sodium borohydride to give 1,4-diallylpiperazine-diborane (V).Ethanolysis of II furnished 1,4-bis(3-diethoxyborylpropyl)piperazine (IV).The products of hydroboration of I were subjected to hydrolysis with hydrochloric acid and subsequent oxidation with alkaline hydrogen peroxide and the obtained mixtures were analyzed by gas-liquid chromatography and mass spectrometry.

Dyestuff-containing microscopic capsule dispersion for record materials

A dyestuff-containing microscopic capsule dispersion for record materials, which comprises at least one methine dyestuff represented by the general formula (I): STR1 wherein X means a phenyl, naphthyl, indolyl, β-styryl, pyridyl, pyrimidyl or pyrazinyl group which may optionally be substituted, R1 -R6 are individually an amino, substituted amino, lower alkyl, cycloalkyl, lower alkoxy or lower haloalkyl group or a halogen or hydrogen atom, R7 and R8 are each a hydrogen or halogen atom or a lower alkoxy group and may be coupled together to form a ring, and said methine dyestuff contains at least one substituted amino group at a position para to the central methine group in the molecule thereof, said methine dyestuff being contained in microscopic capsules; and alkanolamine represented by the general formula (II): STR2 wherein R denotes a lower alkylene, hydroxyalkylene or poly(oxyalkylene) group, R' and R" mean individually a hydrogen atom, an alkyl, hydroxyalkyl, aryl, aralkyl, acyl, or ω-hydroxyalkyl-polyoxyalkylene group or a lower alkyl ether of an ω-hydroxyalkyl-polyoxyalkylene group, and R' and R" may be coupled together to form a ring, and/or a metal ion sequestering agent, said alkanolamine and/or metal ion sequestering agent being contained in said microscopic capsules and/or a liquid medium wherein said microscopic capsules are dispersed.