76725-94-5Relevant academic research and scientific papers
The facile synthesis of O,O-dialkyl α-halobenzylphosphonates from O,O-dialkyl α-hydroxybenzylphosphonates
Green, Donovan,Elgendy, Said,Patel, Geeta,Baban, Jehan A.,Skordalakes, Emmanuel,Husman, Wahid,Kakkar, Vijay V.,Deadman, John
, p. 10215 - 10224 (1996)
O,O-dialkyl α-hydroxybenzylphosphonates (1) can be easily converted in their corresponding α-bromo (2) or α-iodo (3) phosphonates, in quantitative yield, using N,N'-carbonyldiimidazole (CDI) in the presence of allyl bromide or methyl iodide.
Highly efficient green synthesis of α-hydroxyphosphonates using a recyclable choline hydroxide catalyst
Kalla, Reddi Mohan Naidu,Zhang, Yu,Kim, Il
, p. 5373 - 5379 (2017/07/11)
Choline hydroxide has been found to be an efficient basic ionic liquid catalyst for the synthesis of α-hydroxyphosphonates. Hydrophosphonylation of aldehydes was performed via the nucleophilic addition of diethylphosphite to aldehydic carbonyl compounds, in the presence of choline hydroxide under neat as well as solvent conditions. A wide array of substrates, including aromatic, fused aromatic, and heterocyclic aldehydes, were efficiently converted to their corresponding products in good yields. This protocol provides an alternative method for the straightforward synthesis of α-hydroxyphosphonates in high yields.
