767280-48-8Relevant academic research and scientific papers
Synthesis and structure-activity relationships of potent 4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Fukushima, Hiroshi,Hiratate, Akira,Takahashi, Masato,Mikami, Ayako,Saito-Hori, Masako,Munetomo, Eiji,Kitano, Kiyokazu,Chonan, Sumi,Saito, Hidetaka,Suzuki, Akio,Takaoka, Yuji,Yamamoto, Koji
, p. 4093 - 4106 (2008)
Dipeptidyl peptidase IV (DPP-IV) inhibitors are promising antidiabetic drugs, and several drugs are in the developmental stage. We previously reported that the introduction of fluorine to the 4-position of 2-cyanopyrrolidine enhanced the DPP-IV inhibitory
