Basic information

Product Name: methyl (5S,8S,11S,14S)-8-(3-amino-3-oxopropyl)-14-(fluoroacetyl)-5-(2-methoxy-2-oxoethyl)-11-[2-(methylsulfanyl)ethyl]-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate (non-preferred name)
Synonyms: Z-DQMD-FMK;Z-D(OME)QMD(OME)-FMK;CASPASE-3 INHIBITOR V;Z-ASP(OME)-GLN-MET-ASP(OME)-FMK;Z-D(OME)QMD(OME) (FLUOROMETHYLKETONE);Z-DQMD-FMK, Z-Asp(OMe)-Gln-Met-Asp(OMe)-FMK;Z-ASP(OME)-GLN-MET-ASP(OME)-FLUOROMETHYLKETONE;Z-ASP(OME)-GLN-MET-DL-ASP(OME)-FLUOROMETHYLKETONE;BENZYLOXYCARBONYL-ASP(OME)-GLN-MET-ASP(OME)-FLUOROMETHYLKETONE;L-Methioninamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-glutaminyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester
CAS NO:767287-99-0
Molecular Formula: C₂₉H₄₀FN₅O₁₁S
Molecular Weight: 685.7182
EINECS: N/A
Product Categories: Caspases/Apoptosis;Caspase/Related products;Apoptosis

Chemical Properties

Melting Point: N/A
Boiling Point: 1028.9°C at 760 mmHg
Flash Point: 576°C
Appearance: N/A
Density: 1.306g/cm³
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.539
Storage Temp.: ?20°C
Solubility: ≥29.2 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
CAS DataBase Reference: methyl (5S,8S,11S,14S)-8-(3-amino-3-oxopropyl)-14-(fluoroacetyl)-5-(2-methoxy-2-oxoethyl)-11-[2-(methylsulfanyl)ethyl]-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate (non-preferred name)(CAS DataBase Reference)
NIST Chemistry Reference: methyl (5S,8S,11S,14S)-8-(3-amino-3-oxopropyl)-14-(fluoroacetyl)-5-(2-methoxy-2-oxoethyl)-11-[2-(methylsulfanyl)ethyl]-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate (non-preferred name)(767287-99-0)
EPA Substance Registry System: methyl (5S,8S,11S,14S)-8-(3-amino-3-oxopropyl)-14-(fluoroacetyl)-5-(2-methoxy-2-oxoethyl)-11-[2-(methylsulfanyl)ethyl]-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate (non-preferred name)(767287-99-0)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany: 3
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 767287-99-0(Hazardous Substances Data)

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Biological Activity

Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro .

references

1. susan s. chou*, michael s. clegg, alterations in protein kinase c activity and processing during zinc-de?ciency-induced cell death, biochem. j. (2004) 383, 63–71 2. j. h. banga, e. s. han. differential response of mg132 cytotoxicity against small cell lung cancer cells to changes in cellular gsh contents. biochemical pharmacology 68 (2004) 659–666. 3. t. shimohata, h. zhao, εpkc may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model. stroke. 2007;38:375-380

Check Digit Verification of cas no

The CAS Registry Mumber 767287-99-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,7,2,8 and 7 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 767287-99:
(8*7)+(7*6)+(6*7)+(5*2)+(4*8)+(3*7)+(2*9)+(1*9)=230
230 % 10 = 0
So 767287-99-0 is a valid CAS Registry Number.

767287-99-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name	Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethyl ketone

1.2 Other means of identification

Product number	-
Other names	Z-Asp(OMe)-Gln-Met-Asp(OMe) fluoromethylketone

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:767287-99-0 SDS

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