76729-61-8

Downstream Products

• 630110-53-1 6,6-dimethyl-5,6-dihydro-4H-pyran-2-carboxylic acid 2-iodo-5-methyl-phenyl ester 
• 630110-57-5 2-(2-hydroxymethyl-6,6-dimethyl-tetrahydro-pyran-2-yl)-5-methyl-phenol 
• 42482-66-6 3,4,5,6-tetrahydro-2,2,6-trimethyl-6-(4-methylphenyl)-2H-pyran 

Relevant academic research and scientific papers

Cephalotaxane derivatives and their processes of preparation and purification

The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.

Cephalotaxane derivatives and process for their preparation

The present invention concerns a new general process for asymetric hemisynthesis of harringtonines and their analogs, that are alcaloids used in chimiotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and fonctionalization are entirely preformed.