767294-15-5Relevant academic research and scientific papers
Antidepressant activity of carbamates and urea derivatives
Perveen, Shahnaz,Fatima, Nasreen,Khan, Muhammad Aitmaud,Dar, Ahsana,Khan, Khalid M.,Afza, Nighat,Voelter, Wolfgang
, p. 2709 - 2715 (2012)
Thirteen (13) compounds of N-phenyl-O-alkyl carbamates (1 and 3), N,N-diethyl-N′-alkyl/aryl/phenylpiperazinoureas (4-6, 8-12), N-phenyl-N′-phenylpiperazino/imidazoureas (2, 7), and N-ethyl-(N′- phenylpiperazino) thioureas 13 were synthesized and tested for their antidepressant-like activity in mice. It was found that compound N-phenyl-O-heptyl carbamate 1 and N-phenyl-N′-phenylpiperazinourea 2 showed 32.5 and 27.7% antidepressant activity in the forced swim test in mice, respectively. Considering other carbamates it was found that a decrease in alkyl chain length caused a marked decline in the antidepressant activity. Compounds 1-4 show even higher activities in the forced swim test than the standard phenelzine. Springer Science+Business Media, LLC 2011.
Synthesis of carbamate derivatives of biological interest
Perveen, Shahnaz,Fatima, Nasreen,Khan, Khalid Mohammed,Khan, Ajmal,Ali, Muhammad,Choudhary, Muhammad Iqbal
experimental part, p. 338 - 343 (2011/10/05)
A number of carbamates derivatives 1-12 were synthesized and evaluated for their antioxidant, urease inhibition, anticancer, antibacterial, and antifungal activities. N-Ethylamine-N′, N′-diethyl carbamate (4), showed remarkable metal chelating capability
