767305-41-9Relevant academic research and scientific papers
Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists
Bell, Ian M.,Bednar, Rodney A.,Fay, John F.,Gallicchio, Steven N.,Hochman, Jerome H.,McMasters, Daniel R.,Miller-Stein, Cynthia,Moore, Eric L.,Mosser, Scott D.,Pudvah, Nicole T.,Quigley, Amy G.,Salvatore, Christopher A.,Stump, Craig A.,Theberge, Cory R.,Wong, Bradley K.,Zartman, C. Blair,Zhang, Xu-Fang,Kane, Stefanie A.,Graham, Samuel L.,Vacca, Joseph P.,Williams, Theresa M.
, p. 6165 - 6169 (2006)
A rapid analogue approach to identification of spirohydantoin-based CGRP antagonists provided novel, low molecular weight leads. Modification of these leads afforded a series of nanomolar benzimidazolinone-based CGRP receptor antagonists. The oral bioavai
