767342-26-7Relevant academic research and scientific papers
KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE
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Paragraph 0177; 0211, (2020/07/21)
Disclosed herein are kinase inhibitor compounds having structure (I), or a stereoisomer, pharmaceutically acceptable salt, oxide, or solvate thereof, where R1, R2, R3, R4, R5, R6, R7, X, Y, Z, and (AA) are as defined herein. Also disclosed are compositions containing the kinase inhibitor compounds, methods of inhibiting activity of a kinase in a cell, methods of increasing cell proliferation in a population of pancreatic beta cells, methods of treating a subject for a condition associated with insufficient insulin secretion, and methods of treating a subject for a neurological disorder.
COMPOUNDS WHICH BIND TO THE ACTIVE SITE OF PROTEIN KINASE ENZYMES
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Page/Page column 31-32, (2008/06/13)
One or more compounds that are inhibitors of a serine/ threonine kinase, more particularly Rho kinase (ROK, ROCK) can be used in the manufacture of a medicament for treatment or prophylaxis of a condition selected from: an ocular condition including age r
COMPOUNDS WHICH BIND TO THE ACTIVE SITE OF PROTEIN KINASE ENZYMES
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Page 31-32, (2008/06/13)
The present invention relates to a compound and a group of compounds which are inhibitors of Rho kinase (ROK, ROCK). In addition, the invention relates to methods of treatment and use of the compounds in the manufacture of a medicament for application to
COMPOUND LIBRARIES
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Page 27, (2010/02/08)
The present invention relates to compounds capable of binding to the active site of protein kinase enzymes. The invention further relates to libraries of compounds and a family of libraries of compounds for use in screening programmes against protein kinases as well as the individual compounds for use in hit to lead and lead optimisation projects, and similar stages in the drug discovery process. The invention also provides methods for making compounds and libraries.
