76740-20-0

Usage

Uses

Used in Organic Synthesis:
()-S-(3-chloro-2-methyl-3-oxopropyl) benzenecarbothioate serves as a building block in organic synthesis, particularly for the formation of other thioesters and related compounds. Its versatile structure allows for the creation of a wide range of organic molecules, contributing to the development of new chemical entities.
Used in Pharmaceutical Research and Development:
In the pharmaceutical industry, ()-S-(3-chloro-2-methyl-3-oxopropyl) benzenecarbothioate is utilized for research and development purposes. Its unique properties and reactivity make it a promising candidate for the synthesis of novel drug molecules, potentially leading to the discovery of new therapeutic agents.
Used in Industrial Chemical Production:
()-S-(3-chloro-2-methyl-3-oxopropyl) benzenecarbothioate also finds application in the production of various industrial chemicals. Its role as a building block and its reactivity contribute to the synthesis of a range of chemical products used across different industries.
Used in Organic Chemistry Research:
The structural properties and reactivity of ()-S-(3-chloro-2-methyl-3-oxopropyl) benzenecarbothioate make it a valuable tool for studying the behaviors of thioesters and related functional groups in organic chemistry. Researchers can use ()-S-(3-chloro-2-methyl-3-oxopropyl) benzenecarbothioate to gain insights into the mechanisms and reactions involving thioesters, furthering the understanding of organic chemistry principles.

Upstream product

• 74431-50-8 (D)-3-(Benzoylthio)-2-methylpropanoic acid 

Downstream Products

• 72678-54-7 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-furan-2-yl-thiazolidine-4-carboxylic acid 
• 72678-39-8 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-(4-methoxy-phenyl)-thiazolidine-4-carboxylic acid 
• 72679-37-9 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-(4-dimethylamino-phenyl)-thiazolidine-4-carboxylic acid 
• 110949-48-9 (R)-2-[(3-Benzoylsulfanyl-2-methyl-propionyl)-methyl-amino]-3-benzylsulfanyl-propionic acid 
• 72678-52-5 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-naphthalen-1-yl-thiazolidine-4-carboxylic acid 
• 72678-67-2 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-(2-nitro-phenyl)-thiazolidine-4-carboxylic acid 
• 72678-63-8 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-pyridin-4-yl-thiazolidine-4-carboxylic acid 
• 72679-39-1 (R)-2-(4-Acetylamino-phenyl)-3-((S)-3-benzoylsulfanyl-2-methyl-propionyl)-thiazolidine-4-carboxylic acid 
• 72678-74-1 (4R)-3-<(2S)-S-benzoyl-3-mercapto-2-methylpropanoyl>-2-cyclohexyl-4-thiazolidinecarboxylic acid 
• 72679-00-6 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-pyridin-3-yl-thiazolidine-4-carboxylic acid 
• 72678-56-9 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-(5-methyl-furan-2-yl)-thiazolidine-4-carboxylic acid 
• 72679-59-5 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-(5-chloro-2-hydroxy-phenyl)-thiazolidine-4-carboxylic acid 
• 72678-46-7 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-(2-hydroxy-4-methoxy-phenyl)-thiazolidine-4-carboxylic acid 
• 72678-41-2 (R)-3-((S)-3-Benzoylsulfanyl-2-methyl-propionyl)-2-(3,4,5-trimethoxy-phenyl)-thiazolidine-4-carboxylic acid 

Relevant academic research and scientific papers

1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids

A series of 1-[acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids and salts thereof are useful as Angiotensin I converting enzyme inhibitors.

Studies on angiotensin-converting enzyme inhibitors. I. Syntheses and angiotensin-converting enzyme inhibitory activity of 2-(3-merecaptopropionyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives

(3S)-2-[(2S)-mercapto-2-methylpropionyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid [(3S), (2S)-6a] was prepared by the reaction of (3S)-1,2,3,4-tetrahydreoisoquinoline-3-carboxylic acid test-butyl ester [(3S)-2a) or benzyl ester [(3S)-2b] with 3-benzoylthio-2-methylpropionyl chloride (3a), followed by fractional crystallization and removal of the protective group. The absolute configuration of (3S), (2S)-6a was confirmed by X-ray diffraction analysis of the thiazepinol[4,3-b]isoquinoline compound (7) derived from 6a. Resolution of 3-benzoylthio-2-methylpropionic acid (8) was completed by using optically active phenylalanine amide as a resolving agent. The other optical isomers of (3S),(2S)-6a were prepared by the reaction of (3S)- or (3R)-2b with optically active 3a. The in vitro ACE inhibitory activity of each isomer of 6a was evaluated. Among them, (3S),(2S)-6a was found to be the most potent inhibitor with an IC50 value of 8.6X10-9M. Compound (3S),(2S)-6a induced a dose-dependent inhibition of the pressor response to angiotensin 1 after oral administration to normotensive anesthetized rats. Moreover, (3S),(2S)-6a markedly reduced the systolic blood pressure in renal hypertensive rats (RHR) and spontaneously hypertensive rats (SHR). The in vivo ACE inhibitory activity and the hypotensive effects of (3S),(2S)-6a were comparable to those of captopril.