76746-17-3Relevant academic research and scientific papers
REACTIONS OF 2-METHYLPYRAZOLOQUINAZOLIN-9-ONE DERIVATIVES
Hahn, Witold E.,Osinski, Janusz
, p. 411 - 424 (2007/10/02)
The directions of reactions of the titlie compounds (1) with formaldehyde and amines (secondary and primary) and with aromatic aldehydes, have been studied.It has been found that hydrogen atom substitution in position 3 is favorized.As a result of peracet
Pyrazoloquinazolin-9-ones: A New Series of Antiallergic Agents
Sircar, Jagadish C.,Capiris, Thomas,Kesten, Stephen J.,Herzig, David J.
, p. 735 - 742 (2007/10/02)
A new series of antiallergic agents, pyrazoloquinazolin-9-ones, was synthesized and evaluated for inhibitory effects in the rat reaginic passive cutaneous anaphylaxis (PCA) screen.Several analogues were found to be more potent than cromolyn sodium intravenously.Structure-activity relationships are discussed.One of the compounds, 4,9-dihydro-5-methoxy-9-oxopyrazoloquinazoline-2-carboxylic acid (36), was found to be approximately 250 times more potent than cromolyn sodium intravenously.
