76746-81-1

Upstream product

• 29806-60-8 N¹-benzyl-N²-(4-methoxyphenyl)-thiourea 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 622-79-7 benzyl azide 
• 5416-93-3 4-Methoxyphenyl isocyanate 

Downstream Products

• 76746-78-6 C₁₆H₁₈N₄OS*2ClH 
• 1026571-03-8 3-benzyl-1-(4-methoxyphenyl)-1-[4-(4-methoxyphenyl)-4-oxobut-2-enoyl]urea 
• 1415959-02-2 1-benzyl-5-ethyl-3-(4-methoxyphenyl)imidazolidine-2,4-dione 
• 1415959-03-3 1-benzyl-3-(4-methoxyphenyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 1118749-93-1 1-benzyl-3-(4-methoxyphenyl)-5,5-diphenyl-imidazolidine-2,4-dione 

Relevant academic research and scientific papers

Regioselective multicomponent sequential synthesis of hydantoins

The development of new practical and green methods for the synthesis of small heterocycles is an attractive area of research due to the well-known potential of heterocyclic small molecule scaffolds in the drug discovery process. Herein we report a one-pot, three-component sequential procedure for the synthesis of diversely 1,3,5- and 1,3,5,5-substituted hydantoins, in high yields and very mild conditions, using readily accessible starting materials such as azides, iso(thio)cyanates and substituted α-halo-acetic carboxylic acids. This methodology is especially convenient for the synthesis of spiro-hydantoins, which are particularly interesting bioactive compounds in medicinal chemistry. The Royal Society of Chemistry 2012.

Tagged phosphine reagents to assist reaction work-up by phase-switched scavenging using a modular flow reactor

The use of three orthogonally tagged phosphine reagents to assist chemical work-up via phase-switch scavenging in conjunction with a modular flow reactor is described. These techniques (acidic, basic and Click chemistry) are used to prepare various amides

Oxidation of Mixtures of Thioureas: Part VIII - Formation of 3-Amino-4-aryl-5-benzylimino-4,5-dihydro-1,2,4-thiadiazoles

Oxidation of binary mixtures of 1-aryl-3-benzylthioureas and thiourea in acidic ethanol affords 3-amino-4-aryl-5-benzylimino-4,5-dihydro-1,2,4-thiadiazoles (3). 1-Aryl-3-benzylthioureas used are: 1-phenyl-3-benzyl-, 1-p-tolyl-3-benzyl-, 1-benzyl-3-p-chlorophenyl-, 1-p-anisyl-3-benzyl- and 1-benzyl-3-p-nitrophenyl-thioureas.