76753-12-3

Upstream product

• 76753-11-2 2,5-diazido-1,6-di-O-benzoyl-2,5-dideoxy-3,4-O-isopropylidene-L-iditol 

Downstream Products

• 76753-13-4 C₂₂H₂₄N₆O₁₀S₂ 
• 76753-22-5 C₂₂H₂₄N₆O₈S₄ 
• 122079-83-8 2,5-diazido-3-O-(4-azido-2,3-di-O-benzyl-6-O-propionyl-α-D-glucopyranosyl)-1,6-di-O-benzoyl-2,5-dideoxy-L-iditol 

Relevant academic research and scientific papers

1,4;3,6-Dianhydro-2,5-diazido-2,5-dideoxy-hexitols

The invention relates to new stereoisomeric 1,4;3,6-dianhydro-2,5-diazido-2,5-dideoxy-hexitols of the Formula I. These compounds can be prepared by (a) reacting a hexitol derivative of the general Formula II /wherein R is a mesyl or tosyl group/ in an aqueous or anhydrous organic solvent with an alkali metal azide or ammonium azide; or (b) mesylating or tosylating a compound of the Formula III and treating the mixed ester of the general Formula IV thus obtained /wherein R is as stated above/ with a base; or (c) subjecting a compound of the Formula III to debenzoylation and subsequently to partial esterification and treating the compound of the general Formula V thus obtained /wherein R is as stated above/ with a base. The new compounds of the Formula I possess valuable hypnotic properties and can be used in therapy. STR1

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1,4:3,6-DIANHYDRO-2,5-DIAZIDO-2,5-DIDEOXYHEXITOLS

Reaction of 1,4:3,6-dianhydro-2,5-di-O-mesyl- and -tosyl-D-mannitol with sodium azide afforded the 2,5-diazido-L-iditol derivative.The analogous D-glucitol isomer was obtained in a similar reaction starting from the corresponding D-glucitol derivatives, a