76758-01-5

Usage

Uses

Protected Thiourea.

InChI:InChI=1/C20H18N2S/c21-19(23)22-20(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,(H3,21,22,23)

Upstream product

• 76-83-5 trityl chloride 
• 17356-08-0 thiourea 
• 859326-50-4 N-benzoyl-N'-trityl-thiourea 
• 76-84-6 triphenylmethyl alcohol 

Downstream Products

• 302964-24-5 2-amino-N-(2-chloro-6-methylphenyl)-1.3-thiazole-5-carboxamide 
• 76758-15-1 N-(tosylmethyl)-N'-(triphenylmethyl)urea 
• 76757-96-5 N-(tosylmethyl)-N'-(triphenylmethyl)carbodiimide 
• 76758-09-3 5-p-nitrophenyl-2-triphenylmethyloxazole 
• 76758-11-7 5-p-methoxyphenyl-2-triphenylmethylaminooxazole 
• 76758-13-9 5-p-chlorophenyl-2-triphenylmethylaminooxazole 
• 76758-07-1 5-phenyl-2-<(triphenylmethyl)amino>oxazole 
• 14078-30-9 N,N'-Ditrytylurea 
• 76758-02-6 N-(tosylmethyl)-N'-(triphenylmethyl)thiourea 

Relevant academic research and scientific papers

PROCESS FOR PREPARING N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-METHYL-4-PYRIMIDINYL]AMINO] -5-THIAZOLECARBOXAMIDE AND RELATED METABOLITES THEREOF

The present invention is directed to process for the preparation of metabolites as well as the parent compound of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl] amino]-5-thiazolecarboxamide, the compound of formula (I).

SUBSTITUTED ARYLTHIOUREA DERIVATIVES USEFUL AS INHIBITORS OF VIRAL REPLICATION

Substituted arylthiourea compounds of Formula I, and the pharmaceutically acceptable salts of such compounds, useful as antiviral agents, are provided herein. Certain substituted arylthioureas disclosed herein are potent and/ or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions containing one or more substituted arylthiourea compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents are provided herein. Such pharmaceutical compositions may contain a substituted arylthiourea as the only active agent or may contain a combination of a substituted arylthiourea derivative and one or more other pharmaceutically active agents. Methods of treating Hepatitis C viral infections in mammals are also provided herein.

Synthesis of N-(Tosylmethyl)carbodiimides and Their Application in the Synthesis of 2-Amino-1,3-oxazoles from Aldehydes

A series of N-(tosylmethyl)carbodiimides (TosCH2N=C=NR1, 3) have been prepared from the corresponding thioureas.Carbodiimides 3 with R1 = triphenylmethyl or tert-butyl are useful synthons in a new one-step synthesis of 2-(alkylamino)-1,3-oxazoles 10 from aromatic aldehydes.Acid-induced removal of the triphenylmethyl group from 10 gives 2-amino-1,3-oxazoles (11).