767589-65-1Relevant academic research and scientific papers
COMPLEXATION D'IMINOPYRIDINES PAR LE SEL DE ZEISE: VOIE D'ACCES A DES CONJUGUES ESTRADIOL-cis-DICHLORO PLATINE. ETUDE STRUCTURALE DU COMPLEXE cis-PtCl2,H20
Pointeau, Philippe,Patin, Henri,Mousser, Abdelhamid,Marouille, Jean-Yves Le
, p. 263 - 276 (2007/10/02)
In order to synthesize penta- and hexa-gonal platinum(II) metallocycles, bidentate ligands such as iminopyridines (L) have been prepared and characterized.The (2-pyridil)CH=NR1 and (2-pyridil)CH2N=CR1R2 ligands react with Zeise's salt to afford directly the pentagonal chelates PtCl2L.Their structure and the cis-stereochemistry were shown by the usual spectroscopic methods and for cis-PtCl2,H2O by an X-ray diffraction study.On the other hand, the (2-pyridil)(CH2)2N=CR1R2 ligands do not afford the expected hexagonal metallocycles; instead, after complexation at the nitrogen atom of the imine they give rise to the (2-pyridil)ethylamine complex formed after hydrolysis of the coordinated ligands.Complexes trans-1R2>-PtCl2 represent when R1 is estradiol a model for "cytotoxic with delayed activity".
