767615-69-0Relevant academic research and scientific papers
Applying Gewald reaction for the preparation of some novel aminothieno derivatives featuring noroxymorphone skeletal backbone
Bagherpour, Saeed,Mojtahedi, Mohammad M.,Abaee, M. Saeed
, p. 301 - 309 (2020)
A group of noroxymorphone derivatives were subjected to Gewald reaction conditions to prepare their respective aminothieno products. In refluxing piperidine/ethanol, 1a–g reacted with elemental sulfur and malononitrile to produce 2a–g in high yields. Reactions took place in one pot and completed within 4–7 h and products precipitated spontaneously in the reaction mixtures.
