76778-22-8

Basic information

• Product Name: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
• Synonyms: 1-(2-benzhydryloxyethyl)-4-(3-phenylpropyl)piperazine;GBR 12935;1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine;1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine;Piperazine, 1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl)-;N-[3-tert-Butyl-1-(4-Methylphenyl)-1H-pyrazol-5-yl]-N-[4-[2-(4-Morpholinyl)ethoxy]naphthalen-1-yl]urea;GBR-12935, 1-(2 -(diphenylMethoxy) ethyl) -4-(3-phenylpropyl) piperazine;1-(2-(Benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine Maleate
• CAS NO: 76778-22-8
• Molecular Formula: C₂₈H₃₄N₂O
• Molecular Weight: 414.58236
• Product Categories: Dopamine receptor
• Mol File: 76778-22-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 540.6 °C at 760 mmHg
• Flash Point: 143.9 °C
• Appearance: /
• Density: 1.067 g/cm³
• Vapor Pressure: 9.46E-12mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Desiccate at -20°C
• PKA: 7.55±0.10(Predicted)
• CAS DataBase Reference: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride(76778-22-8)
• EPA Substance Registry System: 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride(76778-22-8)

Safety Data

• Hazardous Substances Data: 76778-22-8(Hazardous Substances Data)

Usage

Description

1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride is an N-alkylpiperazine derivative featuring a piperazine core with 2-(benzhydryloxy)ethyl and 3-phenylpropyl groups at positions 1 and 4, respectively. It is a potent and selective inhibitor of dopamine uptake, with a KD value of 5.5 nM in rat striatal membranes.

Uses

Used in Pharmaceutical Industry:
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride is used as a potent and selective dopamine uptake inhibitor for the treatment of various neurological and psychiatric disorders. Its high affinity for dopamine transporters makes it a promising candidate for the development of medications targeting conditions such as Parkinson's disease, attention deficit hyperactivity disorder (ADHD), and addiction.
Used in Research Applications:
In the field of neuroscience research, 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride serves as a valuable tool for studying the role of dopamine in the brain. It can be used to investigate the mechanisms underlying dopamine-related disorders and to develop new therapeutic strategies for these conditions.
Used in Drug Development:
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride is utilized in the development of novel drugs targeting the dopaminergic system. Its potent and selective inhibition of dopamine uptake can be leveraged to create new medications with improved efficacy and reduced side effects compared to existing treatments.
Used in Drug Delivery Systems:
Similar to gallotannin, 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride can also benefit from novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Researchers can explore the use of various organic and metallic nanoparticles as carriers for this compound, aiming to improve its overall effectiveness in treating dopamine-related disorders.

Biological Activity

Potent and selective inhibitor of dopamine uptake (K D = 5.5 nM in rat striatal membranes).

InChI:InChI=1/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2