76781-75-4Relevant academic research and scientific papers
Preparative synthesis of ethyl 5-acyl-4-pyrone-2-carboxylates and 6-aryl-, 6-alkyl-, and 5-acylcomanic acids on their basis
Obydennov,Goncharov,Sosnovskikh, V. Ya.
, p. 2233 - 2242 (2016)
A simple and efficient method for the synthesis of ethyl 5-alkanoyl- and 5-aroyl-4-pyrone-2-carboxylates was developed, which is based on the condensation of 1-R-2-(dimethyl-aminomethylidene)butane-1,3-diones, obtained from 1,3-diketones and dimethylforma
6-Substituted pyranone compounds and their use as pharmaceuticals
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, (2008/06/13)
Compounds are described of the formula STR1 in which R1 is COOR5, CONHR5, cyano, 5-tetrazolyl or R6, where R5 is hydrogen or C1-8 alkyl and R6 is phenyl or naphthyl, the phenyl or naphthyl group being optionally substituted by one or more group selected from halogen, C1-6 alkyl, C1-4 alkoxy, hydroxy, benzyloxy, nitro, trifluoromethyl, carboxyl, C1-4 alkylsulphinyl, C1-4 alkylsulphonyl, N(R5)2, NHCOR5 and SR5 ; R2 is R6 or --CH=CH--R6 when R1 is COOR5, CONHR5, cyano or 5-tetrazolyl, or R2 is --CH=CH--R6 when R1 is R6 ; R3 is hydrogen, C1-6 alkyl, halogen, hydroxy or --OCH2 R6 ; and R4 is hydrogen, C1-6 alkyl or halogen; and salts thereof. The compounds have pharmaceutical properties and in particular are useful in the treatment of immediate hypersensitivity conditions such as asthma.
