76783-44-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-fluoro-3-phenoxyphenyl)-2-hydroxyethanenitrile is used as a reagent for the preparation of pyrethroid compounds, which are widely used as insecticides. These pyrethroids exhibit potent insecticidal activity and are effective against a broad range of pests, making them valuable tools in agriculture and public health.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-(4-fluoro-3-phenoxyphenyl)-2-hydroxyethanenitrile is utilized as a versatile building block for the creation of various organic molecules. Its unique structure allows for further functionalization and modification, enabling the development of new compounds with potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
2-(4-fluoro-3-phenoxyphenyl)-2-hydroxyethanenitrile is also employed in research and development settings, where it can be used to explore the properties and potential applications of novel compounds. Its reactivity and structural features make it an interesting target for studies aimed at understanding the behavior of organic molecules and developing new synthetic methodologies.

Upstream product

• 68359-57-9 4-fluoro-3-phenoxybenzaldehyde 
• 68359-37-5 cyfluthrin 

Downstream Products

• 73602-55-8 4,4,5,5-tetrachloro-2,2-dimethyl-spiropentane-1-carboxylic acid 3-phenoxy-4-fluoro-α-cyanobenzyl ester 

Relevant academic research and scientific papers

Design, synthesis, and insecticidal activities of novel monohalovinylated pyrethroids

A series of novel monohalovinylated pyrethroids are designed and synthesized to replace one halo atom with a hydrogen atom on the double bond of dihalopyrethroids. Bioassays indicate that some of the synthesized compounds, such as 3j and 1j, exhibit high insecticidal activities against mosquitoes (Culex pipiens pallens), oriental armyworms (Mythimna separata), alfalfa aphids (Aphis medicagini), and carmine spider mites (Tetranychus cinnabarinus). Photolytic results of E-cis-1j suggest that monohalovinylated pyrethroids are photodegraded more easily than compound 12.

Biodegradation of β-Cyfluthrin by Fungi

Five fungal species, namely, Trichoderma viride strain 5-2, T. viride strain 2211, Aspergillus niger, A. terricola, and Phanerochaete chrysoporium were screened for degradation study of β-cyfluthrin. Each fungal species was allowed to grow in Czapek dox medium containing β-cyfluthrin (5 mg/mL) as the major carbon source of the medium. The highest degradation of β-cyfluthrin was observed by T. viride 5-2 (T1/2 = 7.07 days), followed by T. viride 2211 (T1/2 = 10.66 days). The degradation of β-cyfluthrin followed first-order kinetics with a fast degradation rate during first 7 days of growth of the fungi. In the case of T. viride strain 5-2, five degradation products were isolated after 20 days of growth of the fungi, out of which three products were identified as α -cyano-4-fluorobenzyl-3-(2,2-dichlorovinyl)-2,2-dimethyl cyclopropane carboxylate, α-cyano-4-fluoro-3-phenoxy benzyl alcohol, and 3(2,2-dichlorovinyl)-2,2-dimethyl cyclopropanoic acid.

Process for producing cyclopropanecarboxylates

There is disclosed a process process for producing a cyclopropanecarboxylate of formula (1): 1which process comprises reacting cyclopropanecarboxylic acid of formula (2): 2with a monohydroxy compound of formula (3): R6OH??(3),in the presence of a catalyst compound comprising an element of to Group 4 of the Periodic Table of Elements.

New arthropodicides

Compounds with arthropodicidal activity having the general formula (I); STR1 wherein R1 is a halo group; or a lower alkyl, lower alkoxy or lower alkylthio group, in each of which the alkyl group may be substituted with one or more halo groups; R2 is hydrogen or a halo or methyl group; or R1 and R2 together form a methylenedioxy, or a difluoro-methylenedioxy group or, R1 and R2 together with the carbon atoms to which they are attached, form an aromatic ring; R3 is hydrogen, CN, or C≡CH; Y is --CH-- or --N--; Z is H or F; and X1, X2, X3, and X4 are the same or different and each is hydrogen or a fluoro, bromo or chloro group; with the proviso that Y is --N-- when Z is H.

Pyrimidine substituted-2,2-dimethylcyclopropane carboxylates useful for combating insect and acarine pests at a locus

A compound of formula: STR1 wherein R2 represents an α-branched alkyl group containing from 3 to 6 carbon atoms, and R represents either (a) hydroxy, halo or alkoxy of up to six carbon atoms, or (b) the group --OR1 where R1 is the residue of an alcohol of formula R1 OH which forms an insecticidal ester with chrysanthemic acid, permethrin acid or cyhalothrin acid. The compounds have insecticidal and acaricidal properties.

Resolution of hemiacetals and alcohols

A process for the resolution of hemiacetal compounds of the formula STR1 wherein A is a hydrocarbon chain containing 1 to 16 groups, the said chain optionally containing at least one heteroatom, at least one unsaturation, the assembly of the group constituting the chain may be a mono- or polycyclic system including a spiro or endosystem and the assembly of chain A and the carbon atoms attached thereto can contain at least one chiral atom or the hemiacetal moiety thereto which can present a chirality due to the dissymetric spatial configuration of the molecule and Y is selected from the group consisting of hydrogen, alkyl of 1 to 18 carbon atoms optionally substituted, --CY3 ' and the β,γbond together with Y can be part of A and Y' is bromine or chlorine and the resolution of alcohols of the formula wherein R is selected from the group consisting of primary, secondary or tertiary alcohol moiety having at least one asymmetric carbon or the remainder of a substituted alcohol with a chirality due to the dissymetric spatial configuration of the entire molecule comprising reacting in an organic solvent diisobutyl aluminum hydride and a racemate or optical isomer of a compound of the formula STR2 wherein A and Y have the above definition to obtain a compound of the formula STR3 and reacting the latter with a racemate or optical isomer of a compound of the formula wherein R has the above definition to obtain a compound of the formula STR4 wherein Y, A and R have the above definitions, separating the diastereoisomers and cleaving the latter to obtain the enantiomers of the hemiacetal of formula III if the racemate was used above or the alcohol of formula IV if the racemate was used above and novel compounds.

Insecticidal cyclopropane carboxylic acid derivatives with 3-unsaturated-side chain

Novel isomers and mixtures thereof of cyclopropane carboxylic acid derivatives with a 3-unsaturated side chain of the formula STR1 The double bond having Z or E geometry and having insecticidal and nematocidal activity as well as plant and animal acaricidal activity.

Esters and thiolesters of unsaturated acids

Esters and thiolesters of α-substituted unsaturated acids, intermediates therefor, synthesis thereof, and the use of said esters and thiolesters and compositions thereof for the control of pests.

Fluoro substituted aryl esters and thiolesters of amino acids

Fluoro substituted aryl esters and thiolesters of amino acids, intermediates therefor, synthesis thereof and the use of said esters and thiolesters and compositions for the control of pests.