768-04-7

Basic information

• Product Name: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)
• Synonyms: Ethanone, 1-cyclohexyl-2-fluoro- (9CI);1-Cyclohexyl-2-fluoro-ethanone
• CAS NO: 768-04-7
• Molecular Formula: C₈H₁₃FO
• Molecular Weight: 144.1866232
• Product Categories: ACETYLHALIDE
• Mol File: 768-04-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)(768-04-7)
• EPA Substance Registry System: Ethanone, 1-cyclohexyl-2-fluoro- (9CI)(768-04-7)

Safety Data

• Hazardous Substances Data: 768-04-7(Hazardous Substances Data)

Upstream product

• 56077-28-2 Bromomethyl cyclohexyl ketone 
• 13898-94-7 3-cyclohexyl-3-oxopropanoic acid 
• 31151-40-3 2-cyclohexyl-1-diazo-2-ethanone 
• 503-20-8 fluoroacetonitrile 
• 931-50-0 cyclohexylmagnesium bromide 

Downstream Products

• 1415314-86-1 C₁₂H₁₉FO₂ 
• 1415314-91-8 C₁₀H₁₇FO 
• 1415315-15-9 C₁₂H₂₁F 
• 75600-48-5 (Z)-1-cyclohexyl-1,2-difluoroethylene 
• 75600-51-0 cis-1-cyclohexyl-1,2-difluoro-1,2-epoxyethane 
• 67835-09-0 1,3-Dicyclohexyl-2,4-difluoro-3-dihydrobutenon-⁽²⁾ 
• 75600-45-2 1-cyclohexyl-1,1,2-trifluoroethane 

Relevant articles and documents

Decarboxylative fluorination of β-Ketoacids with N-fluorobenzenesulfonimide (NFSI) for the synthesis of α-fluoroketones: Substrate scope and mechanistic investigation

Cesium carbonate (Cs2CO3)-mediated decarboxylative fluorination of β-ketoacids using NFSI in the MeCN/H2O mixed solvent system affords α-fluoroketones with a broad scope. Both electron-rich and electron-deficient α-non-substituted β-ketoacids are amenable to this protocol. The mechanistic study indicates that the reaction proceeds through electrophilic fluorination followed by decarboxylation, which is different from the decarboxylative fluorination of normal carboxylic acids.

Formation of chiral fluoroalkyl products through copper-free enantioselective allylic alkylation catalyzed by an NHC ligand

A valuable Cu-free protocol is reported where an NHC ligand has been employed to form quaternary carbon centers bearing fluoroalkyl units. The results obtained, from this allylic substitution, are better in terms of enantioselectivity and regioselectivity compared to the copper catalyzed system.

Synthesis of α-Fluoromethyl Ketones via Allene Epoxides

α-Fluoromethyl ketones are formed via the reaction of allene epoxides with tetrabutylammonium fluoride trihydrate (TBAF*3H2O) in THF.