76822-21-4

Basic information

• Product Name: Danshensu
• Synonyms: SALVIANIC ACID A;SALVIANIC ACID A SODIUM SALT;(r)-a,3,4-trihydroxybenzenepropanoic acid;3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid;Danshensu;dan shen suan a;(R)-2-Hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid;(R)-2-Hydroxy-3-(3,4-dihydroxyphenyl)propionic acid
• CAS NO: 76822-21-4
• Molecular Formula: C₉H₁₀O₅
• Molecular Weight: 198.17
• Product Categories: Plant extracts
• Mol File: 76822-21-4.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 481.5 °C at 760 mmHg
• Flash Point: 259.1 °C
• Appearance: ==
• Density: 1.546
• Vapor Pressure: 4.42E-10mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Water (Slightly)
• PKA: 3.82±0.10(Predicted)
• CAS DataBase Reference: Danshensu(CAS DataBase Reference)
• NIST Chemistry Reference: Danshensu(76822-21-4)
• EPA Substance Registry System: Danshensu(76822-21-4)

Safety Data

• Hazardous Substances Data: 76822-21-4(Hazardous Substances Data)

Usage

Uses

Danshensu increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. Danshensu may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation.

InChI:InChI=1/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1

Upstream product

• 68307-79-9 (Z)-3-(3,4-dihydroxyphenyl)-2-hydroxyacrylic acid 
• 457893-80-0 (-)-(R)-methyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate 
• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 1241892-06-7 benzyl (2R,3S)-2,3-dihydroxy-3-(3,4-dibenzyloxyphenyl)-propionate 
• 54429-62-8 (E)-3-(3,4-bis(benzyloxy)phenyl)acrylic acid 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 1339946-92-7 benzyl (2R)-hydroxy-3-(3,4-dibenzyloxyphenyl)propionate 
• 951288-55-4 (E)-benzyl 3-(3,4-bis(benzyloxy)phenyl)acrylate 
• 55757-13-6 salvianolic acid B 
• 115939-25-8 salvianolic acid B 

Downstream Products

• 20283-92-5 (R)-(+)-rosmarinic acid 
• 1174681-30-1 (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (S)-PGME amide 
• 1174681-32-3 (2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid (R)-PGME amide 
• 1339947-37-3 C₂₂H₂₄N₂O₈ 
• 1339947-31-7 C₁₆H₁₈N₂O₅ 

Relevant articles and documents

New Benzofuran Lignans from Nepeta multifida

The new benzofuran lignans nepetamultin A (1) and B (2) were isolated from flowers of Nepeta multifida L. [Schizonepeta multifida (L.) Briq.; Lamiaceae]. UV and NMR spectroscopic and mass spectrometric data indicated 1 was the 9′9′′′-di-O-methyl ester of schizotenuin A; 2, the 9′-O-methyl ester of schizotenuin C1. Biological studies revealed that 1 and 2 possessed antioxidant and antihyaluronidase activity.

Unveiling the interaction profile of rosmarinic acid and its bioactive substructures with serum albumin

Rosmarinic acid, a phytochemical compound, bears diverse pharmaceutical profile. It is composed by two building blocks: caffeic acid and a salvianic acid unit. The interaction profile, responsible for the delivery of rosmarinic acid and its two substructure components by serum albumin remains unexplored. To unveil this, we established a novel low-cost and efficient method to produce salvianic acid from the parent compound. To probe the interaction profile of rosmarinic acid and its two substructure constituents with the different serum albumin binding sites we utilised fluorescence spectroscopy and competitive saturation transfer difference NMR experiments. These studies were complemented with transfer NOESY NMR experiments. The thermodynamics of the binding profile of rosmarinic acid and its substructures were addressed using isothermal titration calorimetry. In silico docking studies, driven by the experimental data, have been used to deliver further atomic details on the binding mode of rosmarinic acid and its structural components.

Method for preparing salvianolic acid A

The invention discloses a method for preparing salvianolic acid A. The method includes the following steps that firstly, salvianolic acid B is prepared into a solution with the concentration of 35-45 mg/mL by means of NaOH or NaHCO3 with the pH value of 3.5-4.5, the solution is placed in a subcritical water reaction kettle, after the temperature of a heating furnace reaches 170-190 DEG C and is stabilized, the reaction kettle is placed into the heating furnace, the reaction kettle is taken out after 50-70 min and placed in ice water bath or cold water to be cooled, the liquid is taken out and subjected to freeze-drying, and a crude product rich in salvianolic acid A is obtained; secondly, salvianolic acid A is separated and purified by means of high-speed countercurrent chromatography, wherein a solvent system is prepared from petroleum ether, ethyl acetate, n-butyl alcohol and water according to the ratio of 2:3:1:9, 10 mM of trifluoroacetic acid is added to an upper phase to form a stationary phase, 10 mM ammonia water is a lower phase and serves as a mobile phase, the volume of a high-speed countercurrent chromatography column is 200-400 mL, the sample loading amount is 1.0-1.2 g, the rotation speed is 600-1000 rpm, the flow speed is 1-4 mL/min, and the detection wavelength is 280 nm. The method is low in cost, easy to operate and high in efficiency, salvianolic acid crude extracts can be converted on a large scale, and a salvianolic acid A monomeric compound with the purity higher than 98% is separated and prepared.