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76824-99-2 Usage

General Description

6-HYDROXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID is a chemical compound with the molecular formula C10H11NO4. It is a derivative of tetrahydroisoquinoline, which is a class of compounds with pharmacological and physiological activities. This specific compound has been studied for its potential as a neuroprotective agent and its ability to modulate neurotransmitter systems in the brain. Additionally, it has been investigated for its potential use in the treatment of neurological disorders such as Parkinson's disease and Alzheimer's disease. Its structure and properties make it a target for further research into its potential therapeutic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 76824-99-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,8,2 and 4 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 76824-99:
172 % 10 = 2
So 76824-99-2 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name 1,2,3,4-Tetrahydro-6-hydroxyisoquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:76824-99-2 SDS

76824-99-2Relevant articles and documents

Oxidative cyclization of N-methyl-dopa by a fungal flavoenzyme of the amine oxidase family

Lahham, Majd,Pavkov-Keller, Tea,Fuchs, Michael,Niederhauser, Johannes,Chalhoub, Gabriel,Daniel, Bastian,Kroutil, Wolfgang,Gruber, Karl,Macheroux, Peter

, p. 17021 - 17032 (2018/11/21)

Flavin-dependent enzymes catalyze many oxidations, including formation of ring structures in natural products. The gene cluster for biosynthesis of fumisoquins, secondary metabolites structurally related to isoquinolines, in the filamentous fungus Aspergillus fumigatus harbors a gene that encodes a flavoprotein of the amine oxidase family, termed fsqB (fumisoquin biosynthesis gene B). This enzyme catalyzes an oxidative ring closure reaction that leads to the formation of isoquinoline products. This reaction is reminiscent of the oxidative cyclization reported for berberine bridge enzyme and tetrahydrocannabinol synthase. Despite these similarities, amine oxidases and berberine bridge enzyme–like enzymes possess distinct structural properties, prompting us to investigate the structure–function relationships of FsqB. Here, we report the recombinant production and purification of FsqB, elucidation of its crystal structure, and kinetic analysis employing five putative substrates. The crystal structure at 2.6 ? resolution revealed that FsqB is a member of the amine oxidase family with a covalently bound FAD cofactor. N-methyl-dopa was the best substrate for FsqB and was completely converted to the cyclic isoquinoline product. The absence of the meta-hydroxyl group, as e.g. in L-Nmethyl-tyrosine, resulted in a 25-fold lower rate of reduction and the formation of the demethylated product L-tyrosine, instead of a cyclic product. Surprisingly, FsqB did not accept the D-stereoisomer of N-methyltyrosine, in contrast to N-methyl-dopa, for which both stereoisomers were oxidized with similar rates. On the basis of the crystal structure and docking calculations, we postulate a substrate-dependent population of distinct binding modes that rationalizes stereospecific oxidation in the FsqB active site.



Page/Page column 117; 118; 119, (2015/07/16)

The subject matter herein concerns the identification and development of potent synthetic REV-ERB ligands, such as in vivo agonists and antagonists. These compounds allow for characterization of the effects of modulation of this receptor in vivo specifically on circadian behavior and metabolism, and have suitable characteristics for development of medicinal compounds useful for treatment of malconditions such as diabetes, obesity, atherosclerosis, dyslipidemia, a circadian rhythm disorder, coronary artery disease, bipolar disorder, depression, cancer, a sleep disorder, an anxiety disorder, an addiction disorder, a bone-related disorder such osteoporosis, a skeletal muscle disease, e.g., with compromised exercise capacity, or an autoimmune disorder such as psoriasis, multiple sclerosis, inflammatory bowel disease, and others.

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides

Sperlinga, Emanuela,Kosson, Piotr,Urbanczyk-Lipkowska, Zofia,Ronsisvalle, Giuseppe,Carr, Daniel B.,Lipkowski, Andrzej W.

, p. 2467 - 2469 (2007/10/03)

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (6Htc) has been proposed as a rigid mimic of tyrosine conformation in opioid ligand-receptor complex. The significant receptor binding to mu and delta opioid receptors of respective analogues of

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