768398-54-5

Upstream product

• 768398-50-1 [(1S,2S)-2-Hydroxy-1-hydroxymethyl-2-(4-methylsulfanyl-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 16854-32-3 (1S,2S)-(+)-thiomicamine 

Relevant academic research and scientific papers

Synthesis and biological properties of novel sphingosine derivatives

Sphingosine-1-phosphate (S-1P) derivatives such as threo-(2S,3S)-analogues, which are C-3 stereoisomers of natural erythro-(2S,3R)-S-1P, have been synthesized starting from l-serine or (1S,2S)-2-amino-1-aryl-1,3-propanediols (6). threo-(1S,2R)-2-Amino-1-aryl-3-bromopropanols (HBr salt) have also been prepared from 6. The threo-S-1Ps and the threo-amino-bromide derivatives have shown potent inhibitory activity against Ca2+ ion mobilization in HL60 cells induced by erythro-S-1P, suggesting that these compounds would compete with cell surface EDG/S1P receptors.