768399-58-2Relevant academic research and scientific papers
CP6679, a new injectable cephalosporin. Part1: Synthesis and structure-activity relationships
Tsushima, Masaki,Iwamatsu, Katsuyoshi,Umemura, Eijiro,Kudo, Toshiaki,Sato, Yasuo,Shiokawa, Sojiro,Takizawa, Hiromasa,Kano, Yuko,Kobayashi, Kazuko,Ida, Takashi,Tamura, Atsushi,Atsumi, Kunio
, p. 2781 - 2789 (2007/10/03)
A series of cephalosporins bearing a 5,5-fused ring system, an (imidazo[5,1-b]thiazolium-6-yl)methyl group, at the C-3 position were synthesized and evaluated for in vitro antibacterial activities. CP6679 (1s) and its analogues showed potent antibacterial activities against Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. They were also highly active against methicillin-resistant Staphylococcus aureus (MRSA). CP6679 (1s) showed more potent antibacterial activity than ceftazidime (CAZ) or cefpirome (CPR) against Pseudomonas aeruginosa and MRSA. Copyright (C) 2000 Elsevier Science Ltd.
