768401-68-9

Upstream product

• 190080-33-2 tert-butyl (2R)-2-(tert-butyl)-1,3-oxazol-3(2H)-carboxylate 
• 768401-42-9 4-benzyloxy-2-chlorobutanoyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 768401-30-5 tert-butyl (2R,4R)-4-acetyloxy-2-(tert-butyl)-1,3-oxazolane-3-carboxylate 
• 768401-39-4 4-benzyloxy-2-chlorobutanoic acid 
• 768401-36-1 methyl 4-benzyloxy-2-chlorobutanoate 
• 145625-08-7 (2R,4S)-2-tert-butyloxazolidinone-3,4-dicarboxylic acid 3-tert-butyl ester 4-methyl ester 
• 31600-42-7 methyl 4-(benzyloxy)butanoate 

Downstream Products

• 1160616-07-8 tert-butyl (1S,3R,5S,6S,7S)-3-(tert-butyl)-7-chloro-6-hydroxy-7-(2-benzyloxy)ethyl-2-oxa-4-azabicyclo[3.2.0]heptane-4-carboxylate 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure α-amino-β-hydroxy- cyclobutanone derivatives and their transformations into polyfunctional three- and five-membered ring compounds

Ketenes readily cycloadded to (R)-tert-butyldihydrooxazole 2a-d to yield enantiomerically pure bicyclic cyclobutanones. The cycloadditions proceeded with unusual regiochemistry giving predominantly or exclusively protected α-amino-β-hydroxycyclobutanone derivatives. The adducts could be converted into a variety of interesting enantiopure intermediates equipped with many functional groups: α-amino-β-hydroxy cyclopropane carboxylic acid derivatives, α-amino-β-hydroxy succinic acid derivatives, α-amino-β-hydroxy lactones and lactams derivatives.