76842-60-9Relevant academic research and scientific papers
Characterization of scavengers of γ-ketoaldehydes that do not inhibit prostaglandin biosynthesis
Zagol-Ikapitte, Irene,Amarnath, Venkataraman,Bala, Manju,Roberts II, L. Jackson,Oates, John A.,Boutaud, Olivier
scheme or table, p. 240 - 250 (2011/02/22)
Expression of cyclooxygenase-2 (COX-2) is associated with the development of many pathologic conditions. The product of COX-2, prostaglandin H2 (PGH2), can spontaneously rearrange to form reactive γ-ketoaldehydes called levuglandins (LGs). This γ-ketoaldehyde structure confers a high degree of reactivity on the LGs, which rapidly form covalent adducts with primary amines of protein residues. Formation of LG adducts of proteins has been demonstrated in pathologic conditions (e.g., increased levels in the hippocampus in Alzheimer's disease) and during physiologic function (platelet activation). On the basis of knowledge that lipid modification of proteins is known to cause their translocation and to alter their function, we hypothesize that modification of proteins by LG could have functional consequences. Testing this hypothesis requires an experimental approach that discriminates between the effects of protein modification by LG and the effects of cyclooxygenase-derived prostanoids acting through their G-protein coupled receptors. To achieve this goal, we have synthesized and evaluated a series of scavengers that react with LG with a potency more than 2 orders of magnitude greater than that with the ε-amine of lysine. A subset of these scavengers are shown to block the formation of LG adducts of proteins in cells without inhibiting the catalytic activity of the cyclooxygenases. Ten of these selective scavengers did not produce cytotoxicity. These results demonstrate that small molecules can scavenge LGs in cells without interfering with the formation of prostaglandins. They also provide a working hypothesis for the development of pharmacologic agents that could be used in experimental animals in vivo to assess the pathophysiological contribution of levuglandins in diseases associated with cyclooxygenase up-regulation.
Study of bonding characteristics of some new metal complexes of salicylaldoxime (SALO) and its derivatives by far infrared and UV spectroscopy
Ramesh,Umasundari,Das, Kalyan K.
, p. 285 - 297 (2007/10/03)
New metal chelates of copper, lead and zinc with salicylaldoxime (SALO) and its derivatives have been prepared. The chelates have been characterized by elemental analysis, atomic absorption, infrared and UV spectroscopy. SALO behaves as a bidentate ligand forming neutral metal chelates through the phenolic oxygen and the oxime nitrogen. The M-O stretching frequencies for the transition metals show good agreement with the Irving-William's stability order Cu > Zn > Pb. Similar trend is seen for the M-N stretching frequencies in IR and the shift in transitions from UV spectral data for the metal chelates.
