76862-65-2 Usage
General Description
ALPHA-CONOTOXIN GI is a peptide found in the venom of the Conus geographus, a species of cone snail. It is an antagonist of nicotinic acetylcholine receptors, specifically targeting the α9α10 subtype found in the auditory hair cells. This makes it a potentially valuable tool for studying the role of these receptors in hearing and for developing new medications for conditions affecting the auditory system. Additionally, ALPHA-CONOTOXIN GI has shown promise as a potential therapeutic agent for chronic pain and inflammatory disorders due to its ability to inhibit the release of pro-inflammatory compounds from immune cells. Its unique mechanism of action and potential applications make it a subject of ongoing research and interest in the fields of neuroscience and pharmacology.
Check Digit Verification of cas no
The CAS Registry Mumber 76862-65-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,6,8,6 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 76862-65:
(7*7)+(6*6)+(5*8)+(4*6)+(3*2)+(2*6)+(1*5)=172
172 % 10 = 2
So 76862-65-2 is a valid CAS Registry Number.
InChI:InChI=1/C55H80N20O18S4/c1-25-44(83)72-36-21-95-97-22-37(73-45(84)29(56)9-10-42(80)81)52(91)74-38(51(90)69-33(16-40(57)78)54(93)75-12-4-8-39(75)53(92)65-25)23-96-94-20-35(43(58)82)71-50(89)34(19-76)70-48(87)31(14-26-5-2-6-28(77)13-26)67-49(88)32(15-27-17-61-24-64-27)68-47(86)30(7-3-11-62-55(59)60)66-41(79)18-63-46(36)85/h2,5-6,13,17,24-25,29-39,76-77H,3-4,7-12,14-16,18-23,56H2,1H3,(H2,57,78)(H2,58,82)(H,61,64)(H,63,85)(H,65,92)(H,66,79)(H,67,88)(H,68,86)(H,69,90)(H,70,87)(H,71,89)(H,72,83)(H,73,84)(H,74,91)(H,80,81)(H4,59,60,62)/t25-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
76862-65-2Relevant articles and documents
High-throughput production of two disulphide-bridge toxins
Upert, Grégory,Mourier, Gilles,Pastor, Alexandra,Verdenaud, Marion,Alili, Doria,Servent, Denis,Gilles, Nicolas
supporting information, p. 8408 - 8411 (2014/07/22)
A quick and efficient production method compatible with high-throughput screening was developed using 36 toxins belonging to four different families of two disulphide-bridge toxins. Final toxins were characterized using HPLC co-elution, CD and pharmacological studies. This journal is the Partner Organisations 2014.
