76865-46-8

Upstream product

• 7377-04-0 4-(4-bromobutyl)benzoic acid 
• 99-94-5 p-Toluic acid 
• 85431-07-8 ethyl 4-(4-hydroxybutyl)benzoate 

Downstream Products

• 80318-26-9 triethyl ester of 2-(4-(4-carboxyphenyl)butyl)-1,3-propanedioic acid 
• 76865-48-0 ethyl 4-(5-oxopentyl)benzoate 
• 80305-90-4 4-[4-(2-Amino-4-hydroxy-6-oxo-1,6-dihydro-pyrimidin-5-yl)-butyl]-benzoic acid 
• 85430-90-6 4-(9-Acetoxy-5-acetyl-5-tert-butoxycarbonyl-tetradecyl)-benzoic acid ethyl ester 
• 85430-95-1 4-(9-Acetoxy-5-acetyl-tetradecyl)-benzoic acid ethyl ester 
• 85431-14-7 4-(5-Acetyl-9-hydroxy-tetradecyl)-benzoic acid 

Relevant academic research and scientific papers

Quaternary ammonium compounds having muscle relaxation activity

A quaternary ammonium having a muscle relaxation activity compound represented by the formula (I): STR1 wherein R1 represents a methylene, a lower alkylenoxy, a lower alkenylene, a lower alkynylene, --CO--, --COO--, a lower alkylene carbonyloxy, --CH(OR5)--, a lower alkylenecarbonyl, a hydroxy lower alkylene, --O--, --S--, --SO--, or --SO2 --; R2 represents a hydrogen atom, a hydroxy lower alkyl, an aldehyde, a lower alkyl carbonyl, --NO2, or --NHR6 ; R3 represents a hydrogen atom of a group --R1 --(CH2)a --[CH(CH2 A)--CH2 ]b --A; R4 represents an anion; R5 and R6 represent a hydrogen atom or a acetyl; A represents a quaternary ammonium group; a represents an integer of 1 to 8; b represents 0 or 1; m represents an integer of 1 to 4; and (Z) represents a trivalent benzene ring, a trivalent naphthalene ring, a trivalent diphenyl or a trivalent ethane radical.

11,12-Secoprostaglandins. 6. Interphenylene Analogues of Acylhydroxyalkanoic Acids and Related Compounds as Renal Vasodilators

The synthesis is described of a series of interphenylene analogues of the modified 11,12-secoprostaglandins and their sulfonamide isosteres on which we have reported previously.The new compounds are formally derived from members of earlier series by replacement of segments of the methylene chains by phenylene units.Several of these compounds displayed renal vasodilatory activity on iv stat administration to anesthetized dogs. 4-(4-Acetyl-8-hydroxytridecyl)benzoic acid tested additionally in conscious dogs orally caused a significant increase in renal blood flow at 5 mg/kg.

Interphenylene 9-thia-11-oxo-12-aza-prostanoic acids

This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of biological activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives.