769-14-2

Basic information

• Product Name: 1H-Inden-1-one, 2,3-dihydro-3-methyl-, (3R)-
• CAS NO: 769-14-2
• Molecular Formula: C10H10O
• Molecular Weight: 146.189
• Mol File: 769-14-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Inden-1-one, 2,3-dihydro-3-methyl-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Inden-1-one, 2,3-dihydro-3-methyl-, (3R)-(769-14-2)
• EPA Substance Registry System: 1H-Inden-1-one, 2,3-dihydro-3-methyl-, (3R)-(769-14-2)

Safety Data

• Hazardous Substances Data: 769-14-2(Hazardous Substances Data)

Usage

Physical state

White solid

Odor

Faint

Classification

Ketone

Uses

Fragrance ingredient in perfumes and colognes, industrial applications, production of other chemicals (pharmaceuticals, agrochemicals)

Upstream product

• 772-14-5 (R)-3-phenylbutyric acid 
• 74-86-2 acetylene 
• 6072-57-7 3-methylindanone 
• 71-43-2 benzene 
• 23417-79-0 2-(1-methylethenyl)benzaldehyde 
• 4593-90-2 3-phenylbutyric acid 
• 83-33-0 inden-1-one 
• 40774-41-2 3-Bromoindan-1-one 
• 74-88-4 methyl iodide 

Downstream Products

• 767-58-8 (+)-(R)-1-methylindane 
• 66934-79-0 (R)-1-Methyl-3-phenyl-1H-indene 
• 133131-47-2 (R)-3-methyl-indan-1-one-(2,4-dinitro-phenylhydrazone) 

Relevant articles and documents

Exploring the synthetic potential of a marine transaminase including discrimination at a remote stereocentre

The marine transaminase, P-ω-TA, can be employed for the transamination from 1-aminotetralins and 1-aminoindanes with differentiation of stereochemistry at both the site of reaction and at a remote stereocentre resulting in formation of ketone products with up to 93% ee. While 4-substituents are tolerated on the tetralin core, the presence of 3- or 8-substituents is not tolerated by the transaminase. In general P-ω-TA shows capacity for remote diastereoselectivity, although both the stereoselectivity and efficiency are dependent on the specific substrate structure. Optimum efficiency and selectivity are seen with 4-haloaryl-1-aminotetralins and 3-haloaryl-1-aminoindanes, which may be associated with the marine origin of this enzyme. This journal is

Synthesis of Chiral 3-Alkyl-3,4-dihydroisocoumarins by dynamic kinetic resolutions catalyzed by a Baeyer-Villiger Monooxygenase

"Chemical Equation Presented" Baeyer-Villiger monooxygenases have been tested, in the oxidation of racemic benzofused ketones. When employing a single mutant of phenylacetone monooxygenase (M.446G PAMO) under the proper reaction conditions, it was possible to achieve 3-substituted 3,4-dihydroisocoumarins with, high yields and optical purities through regioselective dynamic kinetic resolution processes.

Efficient kinetic resolution in the asymmetric hydrosilylation of imines of 3-substituted indanones and 4-substituted tetralones

Kinetic resolution of the N-methyl imines of 3-substituted indanones and 4-substituted tetralones could be accomplished by hydrosilylation with a chiral titanocene catalyst. N-Methyl imines of 4-substituted tetralones were resolved to yield, after hydrolysis of the unreacted starting materials, ketones with high ee's and the amine products with high diastereomeric and enantiomeric purity. The utility of this process was demonstrated in the synthesis of sertraline.