769-52-8

Usage

Uses

Used in Organic Synthesis:
4-amino-2-methyl-pyrimidine-5-carboxylic acid is used as a building block for the synthesis of more complex organic molecules. Its carboxylic acid group allows for further functionalization, making it a versatile intermediate in the creation of a wide range of compounds.
Used in Pharmaceutical Industry:
4-amino-2-methyl-pyrimidine-5-carboxylic acid is used as a key component in the development of new drugs. Its unique structure and reactivity make it a promising candidate for the design of novel therapeutic agents, particularly in the areas of antiviral, anticancer, and anti-inflammatory treatments.
Used in Agrochemical Industry:
4-amino-2-methyl-pyrimidine-5-carboxylic acid is used as a starting material for the synthesis of agrochemicals, such as pesticides and herbicides. Its potential to be further functionalized allows for the development of new and more effective compounds for agricultural use.
Used in Research and Development:
4-amino-2-methyl-pyrimidine-5-carboxylic acid is used as a research tool in the study of pyrimidine chemistry and its applications. Its unique properties make it an interesting subject for academic and industrial research, leading to a better understanding of its potential uses and the development of new applications.

InChI:InChI=1/C6H7N3O2/c1-3-8-2-4(6(10)11)5(7)9-3/h2H,1H3,(H,10,11)(H2,7,8,9)

Upstream product

• 698-29-3 2-methyl-4-amino-5-cyanopyrimidine 

Downstream Products

• 599-84-8 sulphamerazine 
• 855230-90-9 4-nitro-benzenesulfonic acid-(2-methyl-pyrimidin-4-ylamide) 

Relevant academic research and scientific papers

Synthesis and fungicidal activity of novel 1,2,4-triazole derivatives containing a pyrimidine moiety

A series of novel 1,2,4-triazole derivatives containing a pyrimidine moiety were synthesized and their fungicidal activities were evaluated. The preliminary biological test indicated that some of the target compounds exhibited moderate to good fungicidal activities against the tested plant pathogenic fungi compared with the commercial agent. Among them, compounds 9n and 9o exhibited excellent antifungal activity against Phompsis sp., with the half-maximal effective concentration (EC50) values of 25.4 and 31.6 μg/mL, which were even better than the commercial agent of Pyrimethanil (32.1 μg/mL). Meanwhile, compound 9o showed better fungicidal activities against B. dothidea and B. cinerea with 40.1 and 55.1 μg/mL, respectively, in comparison with that of commercial Pyrimethanil (57.6 and 62.8 μg/mL).

Synthesis and Antiviral Bioactivity of Novel 2-Substituted Methlthio-5-(4-Amino-2-Methylpyrimidin-5-yl)-1,3,4-Thiadiazole Derivatives

A series of novel 2-substituted methlthio-5-(4-amino-2-methylpyrimidin-5-yl-)-1,3,4-thiadiazole derivatives were synthesized, characterized and evaluated for antiviral activities against tobacco mosaic virus (TMV). The preliminary biological results indicated that most compounds exhibit excellent antiviral activity against TMV in vivo. Among these compounds, compounds 9c, 9i, and 9p displayed the similar curative effect against TMV (EC50 = 287.05-322.47 μg/mL) to that of the commercial agent Ningnanmycin (EC50 = 301.83 μg/mL). In particular, compound 9d demonstrated the best curative effect against TMV (EC50 = 266.21 μg/mL), which was better than that of commercial Ningnanmycin.