76904-97-7

Basic information

• Product Name: 3-(S)-3-[2-(R)-2-methoxy-2-phenyl-2-trifluoromethyl]acetoxybutyric acid methyl ester
• CAS NO: 76904-97-7
• Molecular Weight: 334.292
• Mol File: 76904-97-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(S)-3-[2-(R)-2-methoxy-2-phenyl-2-trifluoromethyl]acetoxybutyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(S)-3-[2-(R)-2-methoxy-2-phenyl-2-trifluoromethyl]acetoxybutyric acid methyl ester(76904-97-7)
• EPA Substance Registry System: 3-(S)-3-[2-(R)-2-methoxy-2-phenyl-2-trifluoromethyl]acetoxybutyric acid methyl ester(76904-97-7)

Safety Data

• Hazardous Substances Data: 76904-97-7(Hazardous Substances Data)

Upstream product

• 53562-86-0 (S)-3-hydroxybutyric acid methyl ester 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 

Relevant articles and documents

Bellisosides A-F, six novel acylated triterpenoid saponins from Bellis perennis (compositae)

Six new acylated triterpenoid saponins, bellisosides A-F (1-6), were isolated from the roots of Bellis perennis (Compositae) together with a known saponin, bellissaponin BS2 (7). These saponins which bear polygalacic acid as sapogenin, are bisdesmosidic glycosides. The structures were elucidated on the basis of chemical and physicochemical evidence. The cytotoxic activities of 1-7 against HL-60 human promyelocytic leukemia cells are also reported.

Asymmetric Hydrogenation of 3,5-Dioxoesters Catalyzed by Ru-binap Complex: A Short Step Asymmetric Synthesis of 6-Substituted 5,6-dihydro-2-pyrones

Asymmetric hydrogenation of 3,5-dioxoesters 1a-c using Ru2Cl4((R) or (S)-binap)2(NEt3) as the catalyst gave dominantly anti 3,5-dihydroxyesters 2, which were then converted into unsaturated lactones 5a-b (ca. 80percent e.e.).The pathway of the hydrogenation reaction was also investigated by asymmetric hydrogenation of (R)- or (S)-5-hydroxy-3-oxoesters 8a-c.It was revealed that the Ru-binap catalyzed hydrogenation of 1a-b proceed dominantly via the β-diketone mode.A convenient asymmetric synthesis of hydroxylactone 3c and unsaturated lactone 5c was presented.Key words: 3,5-dioxoester; Ru-binap catalyst; asymmetric hydrogenation; asymmetric synthesis; lactone